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AZD9164

National Institutes of Health

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2 relations

Broader (2)

PiperidinesQuinuclidines

Papers overview

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Review
2017
Review
2017
Long acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs
ABSTRACT Introduction: Long acting muscarinic receptor antagonists (LAMA) reverse airflow obstruction by antagonizing para… 
2016
2016
PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data.
INTRODUCTION Pharmacokinetic-pharmacodynamic (PKPD) modelling can improve safety assessment, but few PKPD models describing drug… 
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Review
2014
Review
2014
Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies
BackgroundAZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in… 
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2013
2013
Local and systemic effects of inhaled AZD9164 compared with tiotropium in patients with COPD.
There is still a need for new agents which improve upon the therapeutic index of tiotropium, the current standard of care for… 
2012
2012
Overcoming non-specific adsorption issues for AZD9164 in human urine samples: consideration of bioanalytical and metabolite identification procedures.
A key challenge in the development of robust bioanalytical methods, for the determination of drug analyte in human urine samples… 
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2011
2011
The discovery of AZD9164, a novel muscarinic M3 antagonist.
The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was… 
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