J. Lötvall

Publications359
h-index66
Citations30,837
Highly Influential Citations1,292
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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Exosomes are vesicles of endocytic origin released by many cells. These vesicles can mediate communication between cells, facilitating processes such as antigen presentation. Here, we show that… Expand
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
We revise and renew the “MISEV2014” guidelines for studies of extracellular vesicles based on evolution of the collective knowledge in the last four years. Expand
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Biological properties of extracellular vesicles and their physiological functions
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer… Expand
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Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
Secreted membrane-enclosed vesicles, collectively called extracellular vesicles (EVs), which include exosomes, ectosomes, microvesicles, microparticles, apoptotic bodies and other EV subsets,… Expand
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Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
The emergence of publications on extracellular RNA (exRNA) and extracellular vesicles (EV) has highlighted the potential of these molecules and vehicles as biomarkers of disease and therapeutic… Expand
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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
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Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways.
IL-17 is a recently discovered cytokine that can be released from activated human CD4+ T lymphocytes. This study assessed the proinflammatory effects of human (h) IL-17 in the airways. In vitro,… Expand
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Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes
Introduction In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles. However,… Expand
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Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease… Expand
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Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier
Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood–brain barrier (BBB). However, the… Expand
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