Piperidines

Recent advances in synthetic methods for the direct α-functionalization of saturated cyclic amines are described. Methods are… Expand

The eco-friendly and highly diastereoselective synthesis of substituted cis-2,6-piperidines and cis-2,6-tetrahydropyrans is… Expand

1,3-Dicarbonyl compounds can be converted to Mannich-type products A or highly functionalized piperidines B in the presence of a… Expand

A new ruthenium-catalyzed direct sp3 C-H to C-C bond transformation is disclosed. Specifically, a method for the alpha-arylation… Expand

A diverse array of biologically active, lipid-soluble alkaloids have been discovered in amphibian skin. Such alkaloids include… Expand

[reaction: see text]. The cyclization of aminoalkenes bearing an electron-withdrawing group on the nitrogen atom was catalyzed by… Expand

From the pK(a) values of the conjugate acids of a large series of hydroxylated piperidines and hexahydropyridazines, a consistent… Expand

A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete… Expand

Reaction of (R)-phenylglycinol with methyl 5-oxopentanoate gave either bicyclic lactam cis-1 (the kinetic product) or its isomer… Expand

We compared the cardiac electrophysiological actions of two types of H1-receptor antagonists--the piperidines, astemizole and… Expand