The discovery of AZD9164, a novel muscarinic M3 antagonist.

  title={The discovery of AZD9164, a novel muscarinic M3 antagonist.},
  author={A. Mete and K. Bowers and E. Chevalier and D. Donald and H. Edwards and K. J. Escott and R. Ford and K. Grime and Ian Millichip and B. Teobald and V. Russell},
  journal={Bioorganic & medicinal chemistry letters},
  volume={21 24},
  • A. Mete, K. Bowers, +8 authors V. Russell
  • Published 2011
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD. 
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