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The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD.
A novel series of muscarinic receptor antagonists was developed, with the aim of identifying a compound with high M3 receptor potency and a reduced risk of dose-limiting side effects with potentialExpand
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The discovery of AZD9164, a novel muscarinic M3 antagonist.
The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as aExpand
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Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment
Introduction: Autotaxin (ATX), a secreted lysophospholipase, plays a central role in the production of the bioactive lipid lysophosphatidic acid (LPA). LPA signals through multiple LPA receptors toExpand
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The Effect of the CXCR1/2 Antagonist SCH257123 in a Mouse Model of Severe Asthma
ObjectiveSevere asthma patient phenotypes are characterised as hard to control by low dose inhaled corticosteroids (ICS) and patients often require high doses of oral steroids for optimum symptom c...
Initial Characterization of A Mouse Model of Severe Asthma
Severe asthma patients have symptoms that are frequently hard to manage with low dose inhaled corticosteroids (ICS) and often need additional high dose oral steroids. Neutrophilic airway inflammati...
The effects of clinically relevant reference agents in a mouse model of severe asthma
Severe asthma is not controlled by normal doses of inhaled or oral corticosteroids. Patients need high dose oral steroids and there is an unmet medical need for new therapies. Neutrophilic airwayExpand
Steroid-resistant inflammation in a mouse model of severe asthma is not inhibited by the combination of theophylline and budesonide
Severe asthma remains a major unmet medical need and results in a significant demand on healthcare costs. One of the key characteristics of the severe phenotype is a neutrophilic inflammation that isExpand