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Quinuclidines

Known as: Quinuclidines [Chemical/Ingredient], quinuclidine 
 

Topic mentions per year

Topic mentions per year

1951-2018
010203019512017

Related topics

Related topics

50 relations

Narrower (45)

2-quinuclidone3-(biphenyl-4-yl)quinuclidine3-aminoquinuclidine3-quinuclidinol
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administration & dosageantagonists & inhibitorsaspects of radiation effectschemical synthesis
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Quinuclidines
Quinine
Quinidine
chemical synthesis
palonosetron
SR 140333

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Quinuclidine derivatives as potential antiparasitics.
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease… (More)
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2007
2007
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
The biosynthesis of sterols is a major route for the development of antitrypanosomals. Squalene synthase (SQS) catalyzes the… (More)
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2007
2007
Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.
The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists… (More)
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2006
2006
Antiproliferative activities of two novel quinuclidine inhibitors against Toxoplasma gondii tachyzoites in vitro.
OBJECTIVES To study the antiproliferative effects of ER119884 and E5700, two quinuclidine-based inhibitors of squalene synthase… (More)
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Highly Cited
2005
Highly Cited
2005
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.
A library of benzamides was tested for alpha7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor… (More)
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2004
2004
Synthesis and biological evaluation of quinuclidine derivatives incorporating phenothiazine moieties as squalene synthase inhibitors.
Squalene synthase inhibitors have the potential to be superior hypocholesterolemic agents. A series of quinuclidine derivatives… (More)
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2003
2003
Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope.
The reactivity of a variety of quinuclidine-based catalysts in the Baylis-Hillman reaction has been examined, and a… (More)
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1999
1999
Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function.
Transmembrane domain 6 of the muscarinic acetylcholine (ACh) receptors is important in ligand binding and in the conformational… (More)
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1997
1997
Nicotinic antagonists (piperidines and quinuclidines) reduce the susceptibility of early sea urchin embryos to agents evoking calcium shock.
1. Some nicotinic antagonists (piperidine and quinuclidine derivatives and bis-quaternary compounds) protect early embryos of the… (More)
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1991
1991
Selectivity and specificity of new, non-peptide, quinuclidine antagonists of substance P.
Two members of a new class of non-peptide antagonists of substance P, (+-)-cis-3-(2-methoxybenzylamino)-2-benzhydrylquinuclidine… (More)
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