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- Publications
- Influence
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
- Tsuyoshi Mikkaichi, T. Suzuki, +15 authors T. Abe
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 9 March 2004
Digoxin, which is one of the most commonly prescribed drugs for the treatment of heart failure, is mainly eliminated from the circulation by the kidney. P-glycoprotein is well characterized as a… Expand
IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis1
- M. Numasaki, M. Watanabe, +8 authors H. Sasaki
- Biology, Medicine
- The Journal of Immunology
- 1 November 2005
In this study, we examined the biological action of IL-17 on human non-small cell lung cancer (NSCLC). Although IL-17 had no direct effect on the in vitro growth rate of NSCLC, IL-17 selectively… Expand
Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.
- H. Yamaguchi, Misa Sugie, +7 authors N. Mano
- Chemistry, Medicine
- Drug metabolism and pharmacokinetics
- 2010
Human organic anion transporter OATP4C1 is a member of the OATP family predominantly expressed in the kidney, and contributes to the renal secretion of digoxin. However, little is known about the… Expand
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
- Takafumi Toyohara, T. Suzuki, +29 authors Takaaki Abe
- Medicine
- Journal of the American Society of Nephrology…
- 29 October 2009
Hypertension in patients with chronic kidney disease (CKD) strongly associates with cardiovascular events. Among patients with CKD, reducing the accumulation of uremic toxins may protect against the… Expand
Identification and characterization of novel rat and human gonad-specific organic anion transporters.
- T. Suzuki, T. Onogawa, +14 authors T. Abe
- Biology, Medicine
- Molecular endocrinology
- 1 July 2003
We have isolated three novel organic anion transporter cDNAs designated rat GST-1 (gonad-specific transporter), rat GST-2, and human GST, expressed at high levels in the testis. Rat GST-1, GST-2, and… Expand
Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 Published, JLR Papers in Press, March 13, 2006.
- H. Yamaguchi, M. Okada, +11 authors J. Goto
- Chemistry, Medicine
- Journal of Lipid Research
- 1 June 2006
This study sought to clarify the contributions of organic anion-transporting polypeptide (OATP) 1B1 and 1B3 to the liver uptake of chenodeoxycholic acid (CDCA). We synthesized a fluorescent version… Expand
Genotyping of the N-acetyltransferase2 polymorphism in the prediction of adverse drug reactions to isoniazid in Japanese patients.
- M. Hiratsuka, Y. Kishikawa, +7 authors M. Mizugaki
- Medicine
- Drug metabolism and pharmacokinetics
- 2002
To investigate the association between NAT2 genotypes and the incidence of isoniazid (INH)-induced adverse reactions, in the hope of identifying a pharmacogenetic approach that could be useful in the… Expand
Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates.
- N. Hazeki, T. Tukamoto, J. Goto, I. Kanazawa
- Chemistry, Medicine
- Biochemical and biophysical research…
- 22 October 2000
Huntington's disease (HD) is caused by an expansion of the CAG repeat that encodes polyglutamine in huntingtin. Transient expression of an N-terminal huntingtin fragment containing an expanded… Expand
High sensitive analysis of rat serum bile acids by liquid chromatography/electrospray ionization tandem mass spectrometry.
- M. Ando, T. Kaneko, +6 authors J. Goto
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 18 March 2006
Sensitive liquid chromatography (LC)/electrospray ionization (ESI) tandem mass spectrometry (MS) can be used to analyze the bile acid composition of rat serum. This method can analyze eight common… Expand
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.
- H. Yamaguchi, M. Kobayashi, +6 authors N. Mano
- Chemistry, Medicine
- Cancer letters
- 18 February 2008
A rapid screening system has been established to extract novel candidates that exhibit potent inhibition of the transport of fluorescent substrate by organic anion transporting polypeptide (OATP)… Expand