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Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
- T. Mikkaichi, Takehiro Suzuki, T. Abe
- BiologyProceedings of the National Academy of Sciences…
- 9 March 2004
Human OATP4C1/rat Oatp4c1 might be a first step of the transport pathway of digoxin and various compounds into urine in the kidney, which is one of the most commonly prescribed drugs for the treatment of heart failure.
IL-17 Enhances the Net Angiogenic Activity and In Vivo Growth of Human Non-Small Cell Lung Cancer in SCID Mice through Promoting CXCR-2-Dependent Angiogenesis1
- M. Numasaki, Mika Watanabe, Hidetada Sasaki
- Biology, ChemistryThe Journal of Immunology
- 1 November 2005
It is demonstrated that IL-17 increases the net angiogenic activity and in vivo growth of NSCLC via promoting CXCR-2-dependent angiogenesis and suggest that targeting CX CR-2 signaling may be a novel promising strategy to treat patients with NSCLCs.
Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.
The results indicate that estrone 3-sulfate does not bind to the recognition site for digoxin in OATP4C1.
Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 Published, JLR Papers in Press, March 13, 2006.
The results suggest that OATP1B1 and OATp1B3 play important roles in CDCA uptake into the liver, and fluorescent bile acids are useful tools to characterize the uptake properties of membrane transporters.
SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.
- T. Toyohara, Takehiro Suzuki, T. Abe
- Biology, MedicineJournal of the American Society of Nephrology…
- 29 October 2009
Overexpression of human kidney-specific organic anion transporter SLCO4C1 in rat kidney reduced hypertension, cardiomegaly, and inflammation and increased the clearance of asymmetric dimethylarginine and trans-aconitate in renal failure, suggesting that drugs that upregulate SLCC1 may have therapeutic potential for patients with CKD.
Identification and characterization of novel rat and human gonad-specific organic anion transporters.
Northern blot analyses and in situ hybridization suggest that rat GST-1 and GST-2 might be one of the molecular entities responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of sex steroid transportation and spermatogenesis in the gonad.
Genotyping of the N-acetyltransferase2 polymorphism in the prediction of adverse drug reactions to isoniazid in Japanese patients.
The results indicated that the genes coding for slow acetylation were associated with the incidence of serious ADRs following INH treatment, suggesting that determination of NAT2 genotype might be clinically useful in the evaluation of patients at high risk of developing ADRs induced by INH.
Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes.
AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes.
This work purified an AMSH-binding protein, CHMP3, which is an ESCRT-III subunit, indicating AMSH might also play a role in MVB/late endosomes, and suggests that both the DUB activity of AMSH and its ChMP3-binding ability are required to clear ubiquitinated cargo from endosome.