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Endocrine cells in human intestine: an immunocytochemical study.
The regional and topographic distribution of endocrine cells in the human intestine was examined by immunohistochemistry and cells displaying beta-endorphin, pro-gamma-melanocyte-stimulating hormone, or beta-lipotropin immunoreactivity, or a combination of these, were found in the small intestine.
Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: Immunocytochemical and immunochemical evidence
The data favour a role for PACAP in primary sensory neurons in the sensory nervous system of the rat, and the immunocytochemical results agreed with those obtained by radioimmunoassay forPACAP and CGRP.
Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Neuropeptide Y greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries.
Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: A study on isolated islets from mouse and rat pancreas
Proghrelin, the precursor of the orexigenic and adipogenic peptide hormone ghrelin, is synthetized in endocrine (A-like) cells in the gastric mucosa. During its cellular processing, proghrelin gives
Pituitary adenylate cyclase activating peptide: A novel vasoactive intestinal peptide-like neuropeptide in the gut
The distribution of PACAP-immunoreactive nerve cell bodies and nerve fibers in the gut wall suggests their involvement in the regulation of both motor and secretory activities.
A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control
Radioimmunoassay demonstrated ghrelin-like material in the rat oxyntic mucosa with moderate amounts also in antrum and duodenum and small amounts were found in the distal intestines and pancreas.
Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides
A C-terminal portion appears to be sufficient for exerting the prejunctional effect of NPY and PYY, while the whole sequence seems to be required for post- junctional effects.
Control of gastric acid secretion:the gastrin-ECL cell-parietal cell axis.
The gastrin-ECL cell pathway has been investigated extensively and studies both in vivo/in situ and in vitro have suggested that while acetylcholine seems capable of activating parietal cells, it does not affect histamine secretion from ECL cells.
Histamine in endocrine cells in the stomach
SummaryAntibodies to histamine were used to examine the localization of the amine in cells of the stomach and upper small intestine of a great variety of species, including cartilaginous and bony
Neuropeptide Y Receptor Subtypes, Y1 and Y2
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, and work has indicated that the Y2-receptor may occur postjunctionally in selected sympathetic effector systems.