Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10.
- K. Folkers, S. Vadhanavikit, S. A. Mortensen
- MedicineProceedings of the National Academy of Sciences…
- 1 February 1985
A myocardial deficiency of CoQ10 is revealed, which is higher with increasing severity of disease and is reduced by therapy, and this biochemistry correlates with the effective treatment of cardiomyopathy with CoQ 10.
Lovastatin decreases coenzyme Q levels in humans.
- K. Folkers, P. Langsjoen, H. Tamagawa
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 November 1990
Data from the three protocols revealed that lovastatin does indeed lower levels of CoQ10, and this reduction would constitute a new risk of cardiac disease, since it is established that Co Q10 is indispensable for cardiac function.
Crystalline Vitamin B12.
- E. Rickes, N. G. Brink, F. Koniuszy, T. R. Wood, K. Folkers
- Chemistry, MedicineScience
- 16 April 1948
The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide.
- J. Bøler, F. Enzmann, K. Folkers, C. Bowers, A. Schally
- BiologyBiochemical and Biophysical Research…
- 6 November 1969
Lovastatin decreases coenzyme Q levels in rats.
- R. Willis, K. Folkers, J. Tucker, C. Ye, L. Xia, H. Tamagawa
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1990
It is concluded that lovastatin does indeed lower tissue concentrations of CoQ and that a return to normal can be achieved by supplementation with CoQ.
A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.
- J. Lundberg, A. Saria, E. Brodin, S. Rosell, K. Folkers
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 February 1983
The data suggest that a major portion of the vagally or capsaicin-induced increase in smooth muscle tone is caused by SP release from sensory neurons, and tracheobronchial afferent SP-containing C fibers may exert local control of smooth muscletone and vascular permeability in normal and pathophysiological conditions.
Evidence for a deficiency of coenzyme Q10 in human heart disease.
- K. Folkers, G. Littarru, L. Ho, T. M. Runge, S. Havanonda, D. Cooley
- MedicineInternationale Zeitschrift fur Vitaminforschung…
- 1970
Response of patients in classes III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10.
- P. Langsjoen, S. Vadhanavikit, K. Folkers
- MedicineProceedings of the National Academy of Sciences…
- 1 June 1985
Patients, steadily worsening and expected to die within 2 years under conventional therapy, generally showed an extraordinary clinical improvement, indicating that CoQ10 therapy might extend the lives of such patients.
Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy.
- P. Langsjoen, P. Langsjoen, K. Folkers
- MedicineAmerican Journal of Cardiology
- 15 February 1990
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