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Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these diseaseExpand
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Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2–4)
Efficacy and safety of tiotropium+olodaterol fixed-dose combination (FDC) compared with the mono-components was evaluated in patients with moderate to very severe chronic obstructive pulmonaryExpand
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How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease?
Evidence-based medicine is a corner stone in treatment decision making and large randomised, clinical trials are usually designed in order to provide highly significant results. This study wasExpand
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Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine.
Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascinExpand
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Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study.
BACKGROUND This phase 3 study further characterizes the efficacy and safety of reslizumab (a humanized anti-IL-5 monoclonal antibody) in patients aged 12 to 75 years with asthma inadequatelyExpand
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Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study.
The purpose of this study was to develop new prediction equations for flow/volume spirometry parameters in asymptomatic, never-smoking adults in Norway, and to assess any differences of theseExpand
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Tiotropium + olodaterol shows clinically meaningful improvements in quality of life.
BACKGROUND Tiotropium + olodaterol improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease (COPD). The OTEMTO 1 and 2 studies investigated the effectsExpand
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IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.
RATIONALE IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES TheExpand
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Achieving asthma control in practice: understanding the reasons for poor control.
Achieving asthma control remains an elusive goal for the majority of patients worldwide. Ensuring a correct diagnosis of asthma is the first step in assessing poor symptom control; this requiresExpand
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Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without "ski asthma".
Bronchial hyperresponsiveness to methacholine with asthma-like symptoms ("ski asthma") is frequent in elite cross-country skiers. To further the understanding of "ski asthma", 10 nonasthmatic,Expand
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