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- Publications
- Influence
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome.
- J. Lötvall, C. Akdis, +7 authors P. Greenberger
- Medicine
- The Journal of allergy and clinical immunology
- 1 February 2011
It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease… Expand
Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2–4)
- R. Buhl, F. Maltais, +16 authors E. Bateman
- Medicine
- European Respiratory Journal
- 8 January 2015
Efficacy and safety of tiotropium+olodaterol fixed-dose combination (FDC) compared with the mono-components was evaluated in patients with moderate to very severe chronic obstructive pulmonary… Expand
How representative are clinical study patients with asthma or COPD for a larger "real life" population of patients with obstructive lung disease?
- K. Herland, Jan-Petter Akselsen, O. Skjønsberg, L. Bjermer
- Medicine
- Respiratory medicine
- 2005
Evidence-based medicine is a corner stone in treatment decision making and large randomised, clinical trials are usually designed in order to provide highly significant results. This study was… Expand
Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine.
- E. Karjalainen, A. Laitinen, M. Sue-Chu, A. Altraja, L. Bjermer, L. Laitinen
- Medicine
- American journal of respiratory and critical care…
- 1 June 2000
Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin… Expand
Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels: A Randomized Phase 3 Study.
- L. Bjermer, C. Lemière, J. Máspero, Sivan Weiss, J. Zangrilli, Matthew Germinaro
- Medicine
- Chest
- 1 October 2016
BACKGROUND
This phase 3 study further characterizes the efficacy and safety of reslizumab (a humanized anti-IL-5 monoclonal antibody) in patients aged 12 to 75 years with asthma inadequately… Expand
Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study.
- A. Langhammer, R. Johnsen, A. Gulsvik, T. Holmen, L. Bjermer
- Medicine
- The European respiratory journal
- 1 November 2001
The purpose of this study was to develop new prediction equations for flow/volume spirometry parameters in asymptomatic, never-smoking adults in Norway, and to assess any differences of these… Expand
Tiotropium + olodaterol shows clinically meaningful improvements in quality of life.
- D. Singh, G. Ferguson, +6 authors L. Bjermer
- Medicine
- Respiratory medicine
- 1 October 2015
BACKGROUND
Tiotropium + olodaterol improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease (COPD). The OTEMTO 1 and 2 studies investigated the effects… Expand
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.
- J. Kearley, J. Erjefalt, +12 authors A. Humbles
- Medicine
- American journal of respiratory and critical care…
- 1 April 2011
RATIONALE
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma.
OBJECTIVES
The… Expand
Achieving asthma control in practice: understanding the reasons for poor control.
- J. Haughney, D. Price, +9 authors L. Bjermer
- Medicine
- Respiratory medicine
- 1 December 2008
Achieving asthma control remains an elusive goal for the majority of patients worldwide. Ensuring a correct diagnosis of asthma is the first step in assessing poor symptom control; this requires… Expand
Bronchoscopy and bronchoalveolar lavage findings in cross-country skiers with and without "ski asthma".
- M. Sue-Chu, L. Larsson, T. Moen, S. Rennard, L. Bjermer
- Medicine
- The European respiratory journal
- 1 March 1999
Bronchial hyperresponsiveness to methacholine with asthma-like symptoms ("ski asthma") is frequent in elite cross-country skiers. To further the understanding of "ski asthma", 10 nonasthmatic,… Expand