Overcoming non-specific adsorption issues for AZD9164 in human urine samples: consideration of bioanalytical and metabolite identification procedures.

@article{Silvester2012OvercomingNA,
  title={Overcoming non-specific adsorption issues for AZD9164 in human urine samples: consideration of bioanalytical and metabolite identification procedures.},
  author={S. Silvester and Frank Zang},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2012},
  volume={893-894},
  pages={
          134-43
        }
}
  • S. Silvester, Frank Zang
  • Published 2012
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • A key challenge in the development of robust bioanalytical methods, for the determination of drug analyte in human urine samples, is the elimination of potential analyte losses as a result of non-specific adsorption to container surfaces in which the samples are collected, stored or processed. A common approach to address adsorption issues is to treat the urine samples with additives that serve to increase analyte solubility and/or minimise interaction with the container surfaces. A series of… CONTINUE READING
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