PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data.

  title={PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data.},
  author={L. Bergenholm and T. Collins and N. Evans and M. Chappell and J. Parkinson},
  journal={Journal of pharmacological and toxicological methods},
  • L. Bergenholm, T. Collins, +2 authors J. Parkinson
  • Published 2016
  • Medicine
  • Journal of pharmacological and toxicological methods
  • INTRODUCTION Pharmacokinetic-pharmacodynamic (PKPD) modelling can improve safety assessment, but few PKPD models describing drug-induced QRS and PR prolongations have been published. This investigation aims to develop and evaluate PKPD models for describing QRS and PR effects in routine safety studies. METHODS Exposure and telemetry data from safety pharmacology studies in conscious beagle dogs were acquired. Mixed effects baseline and PK-QRS/PR models were developed for the anti-arrhythmic… CONTINUE READING
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