• DOI:10.1186/1471-2466-14-52
Corpus ID: 4693331

Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies

@article{Jorup2014TransientPB,
  title={Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies},
  author={C. Jorup and T. Bengtsson and K. Str{\aa}ndgarden and Ulf Sj{\"o}bring},
  journal={BMC Pulmonary Medicine},
  year={2014},
  volume={14},
  pages={52 - 52}
}

C. Jorup, T. Bengtsson, +1 author Ulf Sjöbring

Published 2014

Medicine

BMC Pulmonary Medicine

BackgroundAZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV1 was observed following inhalation of nebulised doses of AZD9164 in citrate buffer.Two additional studies were conducted to further assess the safety and tolerability of multiple ascending doses of AZD9164 in 27 white and 18 Japanese healthy subjects and in 4 patients with COPD. In these… CONTINUE READING

View on Springer

bmcpulmmed.biomedcentral.com

Save to Library

Create Alert

Cite

Launch Research Feed