Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies

@article{Jorup2014TransientPB,
  title={Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies},
  author={C. Jorup and T. Bengtsson and K. Str{\aa}ndgarden and Ulf Sj{\"o}bring},
  journal={BMC Pulmonary Medicine},
  year={2014},
  volume={14},
  pages={52 - 52}
}
  • C. Jorup, T. Bengtsson, +1 author Ulf Sjöbring
  • Published 2014
  • Medicine
  • BMC Pulmonary Medicine
  • BackgroundAZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV1 was observed following inhalation of nebulised doses of AZD9164 in citrate buffer.Two additional studies were conducted to further assess the safety and tolerability of multiple ascending doses of AZD9164 in 27 white and 18 Japanese healthy subjects and in 4 patients with COPD. In these… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Lack of paradoxical bronchoconstriction after administration of tiotropium via Respimat® Soft Mist™ Inhaler in COPD
    • 8
    • PDF
    Local and systemic effects of inhaled AZD9164 compared with tiotropium in patients with COPD.
    • 9
    Inhaled metaproterenol is superior to inhaled cromolyn in protecting against cold-air-induced bronchospasm.
    • 1
    Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: the UPLIFT® trial
    • D. Tashkin
    • Medicine
    • Expert review of respiratory medicine
    • 2010
    • 18
    Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease
    • 17
    Paradoxical bronchospasm associated with the use of inhaled beta agonists
    • 67
    Tiotropium versus salmeterol for the prevention of exacerbations of COPD.
    • 620
    • PDF
    Paradoxical bronchospasm associated with the use of inhaled beta agonists.
    • R. Nicklas
    • Medicine
    • The Journal of allergy and clinical immunology
    • 1990
    • 21
    Safety and pharmacological profile of tiotropium bromide
    • 7