• Publications
  • Influence
Lung deposition and efficacy of inhaled formoterol in patients with moderate to severe COPD.
BACKGROUND Little is known about the impact of COPD on lung deposition of inhaled drugs and the relationship between lung-dose and response of pulmonary function measurements. METHODS NineteenExpand
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Exposure of infants to budesonide through breast milk of asthmatic mothers.
BACKGROUND Maintenance treatment with inhaled corticosteroids is often required for asthmatic nursing women. Data on the transfer of inhaled corticosteroids from plasma to breast milk and theExpand
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Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies
BackgroundAZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initialExpand
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Anti-angiogenic treatment with linomide as adjuvant to surgical castration in experimental prostate cancer.
PURPOSE Escape from "castration inhibition," be it surgical or chemically induced, is still the major problem in prostate cancer treatment. New agents that can be given as adjuvant therapy areExpand
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Pharmacokinetic Evaluation of Once-Weekly and Once-Monthly Buprenorphine Subcutaneous Injection Depots (CAM2038) Versus Intravenous and Sublingual Buprenorphine in Healthy Volunteers Under Naltrexone
AbstractIntroductionCAM2038 q1w (once weekly) and q4w (once monthly) are investigational buprenorphine subcutaneous (SC) formulations based on FluidCrystal® injection depot technology. These two drugExpand
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Absorption and disposition including enterohepatic circulation of (14C) roquinimex after oral administration to healthy volunteers
The absorption and disposition of roquinimex (Linomide®) were studied in four male and two female healthy volunteers. The subjects received a single oral aqueous solution of 14C‐labelled roquinimex,Expand
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The first clinical pilot study of roquinimex (Linomide) in cancer patients with special focus on immunological effects.
Roquinimex (Linomide) has been demonstrated to suppress tumor growth in animal models. The effect is at least in part related to enhanced numbers and activity of natural killer (NK) cells. In thisExpand
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Dissolution rate‐limited absorption and complete bioavailability of roquinimex in man
In order to investigate the bioavailability and the rate‐limiting step of the absorption of roquinimex, an oral solution and a tablet formulation (Linomide®) were given to healthy volunteers. TheExpand
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