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Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373
The ATP‐gated P2X7 receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti‐inflammatory drug discovery. We have recently identified a novelExpand
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Cytoplasmic factors that affect the intensity and stability of bioluminescence from firefly luciferase in living mammalian cells.
In order to improve calibration of firefly luciferase signals obtained by injecting the enzyme into single, isolated heart and liver cells we have investigated why the luminescence from cells isExpand
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Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism.
OBJECTIVES This paper aims to explore the functional significance of the P2X7 receptor in preclinical models of rheumatoid arthritis. METHODS Preclinical studies in vivo were performed using theExpand
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors
A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat P2X7 receptor and provides usefulExpand
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Novel P2X7 receptor antagonists.
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distributionExpand
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Coordinating ecological restoration options analysis and risk assessment to improve environmental outcomes.
Ecological risk assessment as currently practiced has hindered consideration of ecosystem services endpoints and restoration goals in the environmental management process. Practitioners have createdExpand
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The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD.
A novel series of muscarinic receptor antagonists was developed, with the aim of identifying a compound with high M3 receptor potency and a reduced risk of dose-limiting side effects with potentialExpand
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The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
A series of dual CCR3/H(1) antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation ofExpand
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Phosphorus Removal by Struvite Crystallization in Various Livestock Wastewaters
Large dairies and swine farms using flush systems for animal waste management face increasing restrictions on over-application of phosphorus to cropland. The wastewater that the flush systems produceExpand
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Phosphorous Recovery Technology in Conjunction with Dairy Anaerobic Digestion
Phosphorous (P) is a non-renewable resource and an important non-substitutable macronutrient, which exists in nature as phosphates in various inorganic or organic forms. Agriculture, through itsExpand
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