Skip to search formSkip to main contentSkip to account menu

DOPA decarboxylase

Known as: Decarboxylase, Dopa, Dopa Decarboxylase [Chemical/Ingredient] 
One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of DOPA to DOPAMINE. It is of clinical importance in… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (3)

Antiparkinson AgentsAromatic-L-Amino-Acid DecarboxylasesCarboxy-Lyases
DDC geneDOPA decarboxylase activityDopaIn Blood

Narrower (1)

DDC protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
The discovery of central monoamine neurons gave volume transmission to the wired brain
Highly Cited
2005
Highly Cited
2005
Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients.
OBJECTIVE In abstinent alcoholic patients, a low availability of dopamine D2/3 receptors in the ventral striatum and adjacent… 
Highly Cited
2001
Highly Cited
2001
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase
DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation… 
Highly Cited
1999
Highly Cited
1999
High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder.
OBJECTIVE Attention deficit hyperactivity disorder (ADHD) is a highly prevalent childhood psychiatric disorder characterized by… 
Highly Cited
1991
Highly Cited
1991
Dopa decarboxylase activity of the living human brain.
Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4… 
Highly Cited
1985
Highly Cited
1985
Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle.
Review
1980
Review
1980
Nonaminergic striatal neurons convert exogenous l‐dopa to dopamine in parkinsonism
In intact striatum, the enzyme dopa decarboxylase is localized predominantly in dopaminergic nerve terminals. In Parkinson… 
Highly Cited
1972
Highly Cited
1972
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of… 
Highly Cited
1970
Highly Cited
1970
EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN
After the intraventricular injection of 6‐hydroxydopamine (6‐OHDA), there was a long lasting reduction in the brain… 
Highly Cited
1954
Highly Cited
1954
Inhibition of dihydroxy-phenylalanine decarboxylase by derivatives of phenylalanine.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)