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G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic… Expand BACKGROUND
Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus… Expand BACKGROUND
Because of the debate about whether second-generation antipsychotic drugs are better than first-generation… Expand The reason for the high frequency of depression and anxiety in Parkinson's disease is poorly understood. Degeneration of… Expand Because little comparative information is available concerning receptor profiles of antiparkinson drugs, affinities of 14 agents… Expand Hallucinations, mainly of a visual nature, are considered to affect about one-quarter of patients with Parkinson's disease. They… Expand Time is a guiding force in the behavior of all organisms. For both a rat in an experimental setting (e.g. Skinner box) trying to… Expand Although antipsychotic drugs originally helped to discover dopamine receptors, the five dopamine receptors presently identified… Expand The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's… Expand Among 3,775 patients treated with tranquilizers of the phenothiazine group, 1,472 developed extrapyramidal reactions; 21.2% had… Expand