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Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
- R. Spanagel, A. Herz, T. Shippenberg
- Biology, PsychologyProceedings of the National Academy of Sciences…
Data show that tonic activation of mu and kappa receptors is required for the maintenance of basal dopamine release in the nucleus accumbens, which may have implications for the treatment of opiate dependence and affective disorders.
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
It is shown that for a member of this family of receptors (delta opioid receptors in membranes of NG108-15 neuroblastoma-glioma cells), two types of competitive antagonists can be distinguished and one has no intrinsic activity and the second can inhibit GTPase and thus exhibits negative intrinsic activity.
Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.
- R. Bals-Kubik, A. Ableitner, A. Herz, T. Shippenberg
- Biology, PsychologyThe Journal of pharmacology and experimental…
An important role for the A10 neurons in the VTA is suggested in the regulation of both mu and kappa opioid-induced motivational states, whereas aversive effects are associated with the activation of kappa receptors in theVTA and its limbic-cortical terminal regions.
Endogenous opioid systems and alcohol addiction
- A. Herz
- Biology, MedicinePsychopharmacology
Results obtained in genetic models of high preference for alcohol support the view that alcohol intake depends on the activity of the endogenous opioid reward system and that alcohol consumption may serve to compensate for inherent deficits in this system.
Psychotomimesis mediated by kappa opiate receptors
In male subjects, the opiate-active (-)-isomer, but not the (+)- isomer, elicited dose-dependent dysphoric and psychotomimetic effects that were antagonized by naloxone, implying the existence of opposed opioid systems affecting emotional and perceptual experiences.
Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
It is concluded that kappa and mu opioid receptor agonists are effective unconditioned stimuli and that activation of kappa opioid receptors has aversive properties and activation of mu receptors appetitive reinforcing properties.
The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study
It is demonstrated that μ‐, δ‐, and k‐opioid agonists differentially affect DA release in the NAC and this action is centrally mediated.
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
- C. Stein, M. Millan, T. Shippenberg, K. Peter, A. Herz
- BiologyThe Journal of pharmacology and experimental…
- 1 March 1989
The observations suggest that several selective opioid agonists can modulate responses to noxious pressure through a peripheral opioid receptor-specific site of action in inflammation and that these receptors possess distinguishable pharmacological characteristics resembling those of mu, delta and kappa receptors.
Analgesic effect of intraarticular morphine after arthroscopic knee surgery.
Low doses of intraarticular morphine can significantly reduce pain after knee surgery through an action specific to local opioid receptors that reaches its maximal effect three to six hours after injection.