• Publications
  • Influence
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.
TLDR
The findings suggest that psychological and pathological indices are closely related to one another, possibly through their common association with the underlying degenerative process in the brain. Expand
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
TLDR
The results suggest a close relation between changes in the cholinergic system and Alzheimer's dementia, but the precise role of the system in this disease remains to be elucidated. Expand
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
TLDR
In Parkinson's but not Alzheimer's disease the decrease in neocortical (particularly temporal) choline acetyltransferase correlated with the number of neurons in the nucleus of Meynert suggesting that primary degeneration of these cholinergic neurons may be related, directly or indirectly, to declining cognitive function in Parkinson's disease. Expand
CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE
TLDR
A significant positive correlation between the butyrylcholinesterase activities with increasing age (60–90 years) was found in the hippocampus, and the possible connection between cholinergic system pathology and these cholinestersterase abnormalities in Alzheimer dementia is discussed. Expand
Observations on the brains of non-demented old people.
TLDR
Findings must be borne in mind when interpreting the changes in the brains of demented old people, or in the investigation of any other central nervous system disorder in old age. Expand
Pathological changes in the nucleus of meynert in Alzheimer's and Parkinson's diseases
TLDR
Observations, together with major differences in the neuropathology of the nucleus in SDAT and Parkinson's disease (neurofibrillary tangle and Lewy body formation, respectively) suggest that the involvement of the cholinergic system may differ in the two disease processes. Expand
Neurotransmitter enzyme abnormalities in senile dementia Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue
TLDR
Reductions in cerebral GAD require to be interpreted with caution in view of the sensitivity of this enzyme to premortem status but that reductions in cerebral CAT may be a more reliable index of pathological change in senile (Alzheimer-type) dementia. Expand
ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE
TLDR
Aluminium and silicon were found to be colocalised in the central region of senile plaque cores in studies with energy dispersive X-ray microanalysis, suggesting that they may be involved in the initiation or early stages ofsenile plaque formation. Expand
Cell loss in the locus coeruleus in senile dementia of Alzheimer type
Sample counts of the pigmented cells of the locus coeruleus (LC) were performed in 10 middle-aged and 15 old people considered to be intellectually well preserved and in 15 cases of senile dementiaExpand
Blessed-Roth Dementia Scale (DS).
...
1
2
3
4
5
...