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Apomorphine

Known as: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, Apomorphin, Apomorphine [Chemical/Ingredient] 
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (17)

10,11-dihydroxy-N-methylnorapomorphine10,11-methylenedioxy-N-propylnoraporphine2-fluoro-N-n-propylnorapomorphineApokyn

Broader (9)

AlkaloidsAntiparkinson AgentsAporphinesDopamine Agonists
Apomorphine DiacetateIn BloodUprimaagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation
The ipsilateral intrastriatal administration of the specific adenosine A2a receptor agonist, 2-[p-(2-carboxyethyl)phenethylamino… 
Highly Cited
1984
Highly Cited
1984
Separation of peripheral dopamine receptors by a selective DA1 antagonist, SCH 23390.
Intravenous (i.v.) infusions of SCH 23390 (R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7- ol) produced… 
Highly Cited
1981
Highly Cited
1981
Adrenergic and dopaminergic modulation of growth hormone and prolactin secretion in normal and tumor bearing human pituitaries in monolayer culture.
Adrenergic and dopaminergic agonists administered in vivo stimulate GH secretion and inhibit PRL release. To investigate the… 
1978
1978
Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum.
Prompted by an interest in the similarity of brain and tuberoinfundibular systems, the authors studied butaclamol-specific… 
1978
1978
Further identification of multiple responses mediated by dopamine in the CNS of Planorbis corneus.
Intracellular recordings from neurones, receiving monosynaptic contacts from a dopamine-containing (DA-containing) neurone in the… 
Highly Cited
1978
Highly Cited
1978
Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms.
Dopamine and apomorphine produced concentration-dependent inhibition of adrenergic neurotransmission in the isolated, perfused… 
Highly Cited
1976
Highly Cited
1976
Involvement of catecholaminergic and cholinergic mechanisms in the pulsatile release of LH in the long-term ovariectomized rat.
In the long-term ovariectomized rat the secretion of LH has a pulsatile character. In such rats no difference was observed… 
Highly Cited
1975
Highly Cited
1975
Dopamine Induced Relaxation of Isolated Canine Renal, Mesenteric, and Femoral Arteries Contracted with Prostaglandin F2α
The purpose of this investigation was to develop a system for studying the effects of dopamine on isolated blood vessels. Canine… 
Highly Cited
1975
Highly Cited
1975
Quantitative microfluorimetry of formaldehyde induced fluorescence of dopamine in the caudate nucleus.
Quantitative microfluorimetric studies were carried out on the formaldehyde induced fluorescence of dopamine in nerve terminals… 
Highly Cited
1953
Highly Cited
1953
New antiemetic drug; preliminary report.
Nausea and vomiting constitute a symptom complex as distressing and almost as common as pain. It is surprising how little had… 
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