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Apomorphine

Known as: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, Apomorphin, Apomorphine [Chemical/Ingredient] 
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (17)

10,11-dihydroxy-N-methylnorapomorphine10,11-methylenedioxy-N-propylnoraporphine2-fluoro-N-n-propylnorapomorphineApokyn

Broader (9)

AlkaloidsAntiparkinson AgentsAporphinesDopamine Agonists
Apomorphine DiacetateIn BloodUprimaagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1986
1986
Comparison of mandibular movement trajectories and associated patterns of oral muscle electromyographic activity during spontaneous and apomorphine-induced rhythmic jaw movements in the guinea pig.
Vertical and horizontal movements of the lower jaw (mandible) of ketamine-anesthetized guinea pigs were recorded in association… 
Highly Cited
1984
Highly Cited
1984
Separation of peripheral dopamine receptors by a selective DA1 antagonist, SCH 23390.
Intravenous (i.v.) infusions of SCH 23390 (R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7- ol) produced… 
1978
1978
Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum.
Prompted by an interest in the similarity of brain and tuberoinfundibular systems, the authors studied butaclamol-specific… 
1978
1978
Further identification of multiple responses mediated by dopamine in the CNS of Planorbis corneus.
Intracellular recordings from neurones, receiving monosynaptic contacts from a dopamine-containing (DA-containing) neurone in the… 
Highly Cited
1976
Highly Cited
1976
Involvement of catecholaminergic and cholinergic mechanisms in the pulsatile release of LH in the long-term ovariectomized rat.
In the long-term ovariectomized rat the secretion of LH has a pulsatile character. In such rats no difference was observed… 
Highly Cited
1975
Highly Cited
1975
Dopamine Induced Relaxation of Isolated Canine Renal, Mesenteric, and Femoral Arteries Contracted with Prostaglandin F2α
The purpose of this investigation was to develop a system for studying the effects of dopamine on isolated blood vessels. Canine… 
1975
1975
Cholinergic effects of molecular segments of apomorphine and dopaminergic effects of N,N-dialkylated dopamines.
The hydrochlorides of molecular segments of apomorphine [2-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline, 2-(3'4… 
1975
1975
Suppression of mouse killing and apomorphine-induced social aggression in rats by local anesthesia of the mystacial vibrissae.
Local anesthesia of the facial epidermis can effect a substantial decrease in shock-elicited fighting of paired rats. The present… 
1971
1971
Induction and inhibition of in vivo glucuronidation of apomorphine in mice.
The effect of various inducers and inhibitors of drug-metabolizing enzyme systems was studied on the kinetics of apomorphine… 
Highly Cited
1953
Highly Cited
1953
New antiemetic drug; preliminary report.
Nausea and vomiting constitute a symptom complex as distressing and almost as common as pain. It is surprising how little had…