Apomorphine

Known as: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, Apomorphin, Apomorphine [Chemical/Ingredient] 
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1944-2017
010020030019442016

Papers overview

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Highly Cited
2005
Highly Cited
2005
Continuous subcutaneous (SC) infusion of the dopamine agonist apomorphine was shown in retrospective studies to improve drug… (More)
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Highly Cited
2001
Highly Cited
2001
This study examines the effect of apomorphine (APO), a nonselective D(1)- and D(2)-dopamine receptor agonist, on the firing… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVES To determine whether continuous waking day dopaminergic stimulation with the dopamine agonist apomorphine can reduce… (More)
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Highly Cited
1996
Highly Cited
1996
We used positron emission tomography (PET) to measure brain activity in healthy control subjects and unmedicated patients with… (More)
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Highly Cited
1995
Highly Cited
1995
Neonatal excitotoxic hippocampal damage in the rat results in postpubertal onset of a variety of abnormal behaviors related to… (More)
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Highly Cited
1993
Highly Cited
1993
In the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease, controversy exists concerning the use of… (More)
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Highly Cited
1992
Highly Cited
1992
Using positron emission tomography (PET) we previously showed that activation of the putamen, supplementary motor area, and… (More)
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Highly Cited
1991
Highly Cited
1991
Previous work suggests that the dopamine agonist apomorphine decreases prepulse inhibition (PPI) of the acoustic startle response… (More)
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Highly Cited
1976
Highly Cited
1976
Rats learned to press a lever for intravenous injections of amphetamine or apomorphine. They also learned to avoid the taste of… (More)
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Highly Cited
1975
Highly Cited
1975
Eight mug of 6-hydroxydopamine (6-OHDA) injected bilaterally into the nucleus accumbens septi (NAS) or the caudate nucleus of the… (More)
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