• Publications
  • Influence
Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine
The receptor binding profile of olanzapine is consistent with the antidopaminergic, antiserotonergic, and antimuscarinic activity observed in animal models and predicts atypical antipsychotic activity in man. Expand
Atypical Antipsychotics: Mechanism of Action
  • P. Seeman
  • Medicine, Psychology
  • Canadian journal of psychiatry. Revue canadienne…
  • 1 February 2002
Tight and loose bind data agree with the rates of an tipsy chotic dis so cia tion from the human- cloned D2 recep tor and match clini cal brain-imaging find ings that show the newer drugs block 5-HT2A. Expand
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine. Expand
The Creation of Psychopharmacology
  • P. Seeman
  • Psychology
  • Nature Medicine
  • 1 November 2002
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
Trace amines have been implicated in a number of neuropsychiatric disorders including depression and schizophrenia. Although long known to modulate neurotransmission indirectly through the release ofExpand
Brain dopamine receptors.
  • P. Seeman
  • Biology, Medicine
  • Pharmacological reviews
  • 1 September 1980
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity. Expand
The membrane actions of anesthetics and tranquilizers.
  • P. Seeman
  • Chemistry, Medicine
  • Pharmacological reviews
  • 1 December 1972
A diagrammatic summary of the membrane actions of anesthetics and tran-quilizers is shown, and the membrane fluidization may explain the enhanced neurosecretion of membrane-bound materials, by a mechanism of membranes-membrane fusion. Expand
“Breakthrough” Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time
It is shown that during ongoing treatment with clinically relevant doses, haloperidol and olanzapine progressively lose their efficacy in suppressing amphetamine-induced locomotion and conditioned avoidance responding and is linked to an increase in D2 receptor number and sensitivity. Expand
All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors
  • P. Seeman
  • Medicine
  • CNS neuroscience & therapeutics
  • 1 April 2011
Why individuals with schizophrenia are generally supersensitive to dopamine‐like drugs such as amphetamine or methyphenidate is reviewed and whether the D2High state is a common basis for dopamine supersensitivity in the animal models of schizophrenia is reviewed. Expand