P. Seeman | Semantic Scholar

Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

F. Bymaster, D. Calligaro, D. Wong
Psychology, Medicine
Neuropsychopharmacology
1 February 1996

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

H. V. Tol, J. Bunzow, O. Civelli
Psychology, Biology
Nature
18 April 1991

The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine.

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Atypical Antipsychotics: Mechanism of Action

P. Seeman
Medicine
Canadian journal of psychiatry. Revue canadienne…
1 February 2002

Tight and loose bind data agree with the rates of an tipsy chotic dis so cia tion from the human- cloned D2 recep tor and match clini cal brain-imaging find ings that show the newer drugs block 5-HT2A.

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The Creation of Psychopharmacology

P. Seeman
Psychology
Nature Medicine
1 November 2002

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The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia

T. Wolinsky, C. Swanson, C. Gerald
Biology, Psychology
Genes, brain, and behavior
1 October 2007

Trace amines have been implicated in a number of neuropsychiatric disorders including depression and schizophrenia. Although long known to modulate neurotransmission indirectly through the release of…

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Brain dopamine receptors.

P. Seeman
Biology
Pharmacological reviews
1 September 1980

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The membrane actions of anesthetics and tranquilizers.

P. Seeman
Biology
Pharmacological reviews
1 December 1972

A diagrammatic summary of the membrane actions of anesthetics and tran-quilizers is shown, and the membrane fluidization may explain the enhanced neurosecretion of membrane-bound materials, by a mechanism of membranes-membrane fusion.

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Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

R. Sunahara, H. Guan, H. Niznik
Biology, Medicine
Nature
18 April 1991

The cloning of a gene encoding a 477-amino-acid protein with strong homology to the cloned Dt receptor is reported here the existence of a dopamine D1-like receptor with these characteristics had not been predicted and may represent an alternative pathway for dopamine-mediated events and regulation of D2 receptor activity.

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Dopamine receptors and the dopamine hypothesis of schizophrenia

P. Seeman
Psychology, Biology
Synapse
1987

Direct evidence that neuroleptics selectively blocked dopamine receptors occurred in 1974 with the finding that nanomolar concentrations of these drugs stereoselectively inhibited the binding of [3H]‐dopamine or [3h]‐haloperidol.

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D1 and D2 dopamine receptor mRNA in rat brain.

D. Weiner, A. Levey, M. Brann
Biology
Proceedings of the National Academy of Sciences…
1 March 1991

Insight is provided into the neuroanatomical basis of the differential effects of drugs that act on D1 or D2 receptors by mapping the cellular expression of the corresponding mRNAs in rat brain by in situ hybridization histochemistry.

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