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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.
- D. Blum-Degen, T. Müller, W. Kuhn, M. Gerlach, H. Przuntek, P. Riederer
- Neuroscience letters
Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD)… Expand
S-100 protein: serum marker of focal brain damage after ischemic territorial MCA infarction.
BACKGROUND AND PURPOSE Elevations of protein S-100 (S-100) in cerebrospinal fluid and serum have been reported after cerebral infarctions. The aim of our study was to evaluate the time course of… Expand
Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
- S. Nuber, E. Petrasch‐Parwez, +18 authors O. Riess
- Biology, Medicine
- The Journal of Neuroscience
- 5 March 2008
α-Synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. These disorders are characterized by various neurological and… Expand
Basal ganglia alterations and brain atrophy in Huntington’s disease depicted by transcranial real time sonography
- T. Postert, B. Lack, +7 authors T. Büttner
- Journal of neurology, neurosurgery, and…
- 1 October 1999
OBJECTIVES AND METHODS Transcranial real time sonography (TCS) was applied to 49 patients with Huntington’s disease and 39 control subjects to visualise alterations in the echotexture of the basal… Expand
Increased susceptibility to sporadic Parkinson's disease by a certain combined α‐synuclein/apolipoprotein E genotype
- R. Krüger, A. Menezes Vieira‐Saecker, +11 authors O. Riess
- Biology, Medicine
- Annals of neurology
- 1 May 1999
Parkinson's disease (PD) is one of the most common neurodegenerative disorders affecting about 1% of Western populations older than age 50. The pathological hallmark of PD are Lewy bodies, that is,… Expand
Genetic analysis of immunomodulating factors in sporadic Parkinson's disease
Summary. Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the… Expand
Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease.
INTRODUCTION Several lines of evidence suggest that neuroimmune mechanisms may also be involved in neurodegeneration in Parkinson's disease (PD). The potential role of cytokines such as interleukin 6… Expand
Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
Features of Parkinson's disease (PD) include oxidative stress, nigral mitochondrial complex I deficiency and visual dysfunction, all of which are also associated with coenzyme Q(10) (CoQ(10))… Expand