K. Fuxe

Publications1,646
h-index137
Citations89,198
Highly Influential Citations1,516
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EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine
TLDR
The results strongly support the idea that the β2-containing neuronal nicotinic acetylcholine receptor is involved in mediating the reinforcing properties of nicotine.
Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
Increasing evidence suggests that antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the basal ganglia are involved in the motor depressant effects of…
Localization of monoamines in the lower brain stem
Histochemische und pharmakologische Experimente sprechen stark dafür, dass Dopamin, Noradrenalin und 5-Hydroxitryptamin im Hirnstamm der Ratte in drei Typen von Nervenzellen und Endsynapsen…
Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors*
TLDR
The results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D2R are involved.
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.
  • K. Fuxe
  • Biology, Medicine
    Acta physiologica Scandinavica. Supplementum
  • 1965
Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.
A monoclonal antibody against the rat liver glucocorticoid receptor was used in combination with rabbit antibodies against tyrosine hydroxylase, phenylethanolamine N-methyltransferase, and…
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: Implications for striatal neuronal function
TLDR
The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function.
Detection of heteromerization of more than two proteins by sequential BRET-FRET
TLDR
Using SRET, complexes of cannabinoid CB1, dopamine D2 and adenosine A2A receptors in living cells are identified and will allow us to better understand how signals are integrated at the molecular level.
Evidence for the existence of monoamine neurons in the central nervous system
  • K. Fuxe
  • Chemistry, Biology
    Zeitschrift für Zellforschung und Mikroskopische…
  • 9 February 1965
TLDR
All the data strongly support the view that the specific central neurons giving rise to the terminals are monoaminergic, i.e. function by releasing their amines from the synaptic terminals, Consequently, DA, NA and 5-HT seem to be central neurotransmitters.
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