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VPS35 mutations in Parkinson disease.
Validation of the freezing of gait questionnaire in patients with Parkinson's disease
TLDR
FOG‐Q was a reliable tool for the assessment of treatment intervention and was best correlated to items of the UPDRS relating to walking, general motor issues, and mobility.
Antioxidant Therapy in Acute Central Nervous System Injury: Current State
TLDR
Treatment with antioxidants may theoretically act to prevent propagation of tissue damage and improve both the survival and neurological outcome of acute central nervous system (CNS) injury.
The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy
TLDR
Well-designed clinical studies using antioxidant intake, as well as investigations based on larger cohorts studied over a longer periods of time, are needed in order to assess whether antioxidant intake together with other conventional treatments, might be beneficial in treating MS.
A double-blind, delayed-start trial of rasagiline in Parkinson's disease.
TLDR
Early treatment with rasagiline at a dose of 1 mg per day provided benefits that were consistent with a possible disease-modifying effect, but early treatment with the two doses were associated with different outcomes, the study results must be interpreted with caution.
Precursor control of neurotransmitter synthesis.
TLDR
This relationship allows precursor administration to produce selective physiologic effects by enhancing neurotransmitter release from some but not all of the neurons potentially capable of utilizing the precursor for this purpose, and allows the investigator to predict when administering the precursor might be useful for amplifying a physiologic process, or for treating a pathologic state.
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