• Publications
  • Influence
Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance.
We examined effects of very low doses of melatonin (0.1-10 mg, orally) or placebo, administered at 1145 h, on sleep latency and duration, mood, performance, oral temperature, and changes in serumExpand
  • 548
  • 25
Brain serotonin content: physiological regulation by plasma neutral amino acids.
When plasma tryptophan is elevated by the injection of tryptophan or insulin, or by the consumption of carbohydrates, brain tryptophan and serotonin also rise; however, when even larger elevations ofExpand
  • 447
  • 24
  • PDF
Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.
Altered processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease. To investigate whetherExpand
  • 879
  • 22
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan (12.5 milligrams per kilogram. intraperitoneally) smaller than one-twentieth ofExpand
  • 961
  • 17
  • PDF
Effects of exogenous melatonin on sleep: a meta-analysis.
Exogenous melatonin reportedly induces drowsiness and sleep, and may ameliorate sleep disturbances, including the nocturnal awakenings associated with old age. However, existing studies on theExpand
  • 388
  • 14
  • PDF
Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial.
Souvenaid aims to improve synapse formation and function. An earlier study in patients with Alzheimer's disease (AD) showed that Souvenaid increased memory performance after 12 weeks in drug-naïveExpand
  • 218
  • 14
  • PDF
Precursor control of neurotransmitter synthesis.
Studies performed during the past decade have shown that the rates at which certain neurons produce and release their neurotransmitters can be affected by precursor availability, and thus by theExpand
  • 631
  • 13
Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet
In the rat, the injection of insulin or the consumption of carbohydrate causes sequential increases in the concentrations of tryptophan in the plasma and the brain and of serotonin in the brain.Expand
  • 675
  • 11
  • PDF
Evidence for a membrane defect in Alzheimer disease brain.
To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels of the major membrane phospholipidsExpand
  • 478
  • 11
  • PDF
Diurnal variations in plasma concentrations of tryptophan, tryosine, and other neutral amino acids: effect of dietary protein intake.
The effect of dietary protein content on the diurnal variations in plasma neutral amino acid levels was studied in normal human subjects. For three consecutive 5-day periods, subjects consumed dietsExpand
  • 233
  • 11