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A New Method to Measure Brain Serotonin Synthesis in vivo. I. Theory and Basic Data for a Biological Model
- M. Diksic, S. Nagahiro, T. Sourkes, Y. Yamamoto
- BiologyJournal of cerebral blood flow and metabolism…
- 1 January 1990
An autoradiographic method is described to measure the in vivo rate of serotonin synthesis in rat brain, based on the use of the l-tryptophan analogue a-methyl-l-tiptophan (a-MTrp), which is converted in vivo into a-M5HT.
Serotonin Synthesis Rate Measured in Living Dog Brain by Positron Emission Tomography
- M. Diksic, S. Nagahiro, T. Chaly, T. Sourkes, Y. Yamamoto, W. Feindel
- Biology, ChemistryJournal of neurochemistry
- 1 January 1991
Abstract: In vivo measurements by positron emission tomography of the brain serotonin synthesis rates in the normal dog, in the dog with increased plasma tryptophan concentration, and in the dog…
Excretion of Dopamine in Diseases of Basal Ganglia
The urinary excretion of catecholamines has been measured in 32 patients with disorders of the basal ganglia; the lowest mean value of urinary dopamine was found in postencephalitic Parkinsonism; the highest occurred in Wilson's disease.
The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat.
Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.
- S. Young, S. Lal, T. Sourkes, F. Feldmuller, A. Aronoff, J. Martin
- Biology, ChemistryJournal of neurology, neurosurgery, and…
- 1 April 1975
In this cross-sectional study, for the controls and in patients with advanced hepatic cirrhosis, CSF tryptophan was correlated significantly and positively with the total serum but not with the free serum tryPTophan, and administration of probenecid, which displaces trypsophan from binding sites on serum albumin, did not affect CSFtryptophans.
Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid1
Most of the HVA appears to enter the ventricular system at the lateral ventricles, whereas much of the 5-HIAA in CSF originates in lower neuronal structures, including the spinal cord.
Parallel variation of ventricular CSF tryptophan and free serum tryptophan in man.
The data suggest that, in man, brain tryptophan concentrations are influenced by the free and not the total serum tryPTophan and that physiological variations of the neutral amino acids do not appreciably influence the concentration of brain trytophan.
Apomorphine and Its Relation to Dopamine in the Nervous System
Apomorphine was synthesized from morphine over one hundred years ago and was soon recognized as a powerful emetic agent, but until recently little attention was paid to its stereotypic properties with the exception of the work of Morita and Amsler (1923).
Functional cerebral activity of an analogue of serotonin formed in situ
Gradients of concentrations of tryptophan and 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF).
A study of CSF tryptophan in patients with hepatic cirrhosis provided no support for theories which implicate abnormal tryPTophan metabolism as a cause of hepatic coma, and gradients of concentration of these substances indicate that trypsophan and 5-HIAA probably enter the CSF from all levels of the nervous system, but that HVA originates entirely in the brain.