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Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
Evidence is provided that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be transferred between cells, which may help the understanding of some diseases due to mitochondrial alterations.
Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors*
The results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D2R are involved.
Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain.
- A. Härfstrand, K. Fuxe, H. Steinbusch
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1986
A monoclonal antibody against the rat liver glucocorticoid receptor was used in combination with rabbit antibodies against tyrosine hydroxylase, phenylethanolamine N-methyltransferase, and…
Detection of heteromerization of more than two proteins by sequential BRET-FRET
Using SRET, complexes of cannabinoid CB1, dopamine D2 and adenosine A2A receptors in living cells are identified and will allow us to better understand how signals are integrated at the molecular level.
The discovery of central monoamine neurons gave volume transmission to the wired brain
Targeting adenosine A2A receptors in Parkinson's disease
Intercellular communication in the brain: Wiring versus volume transmission
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes.
- S. Ginés, J. Hillion, R. Franco
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 18 July 2000
The A(1)R/D( 1)R heteromerization may be one molecular basis for the demonstrated antagonistic modulation of A(2)R of D(1]R receptor signaling in the brain and seems to be essential for the blockade of A-1-R agonist-induced A(3)R-induced coclustering and for the desensitization of the D(0)R agonists cAMP accumulation.
Understanding wiring and volume transmission
Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor.
It is suggested that the hypothalamic GR may be involved in the regulation of especially CRF secretion but also in the secretion of other anterior pituitary hormones such as TRH and somatostatin.