DDC protein, human

Known as: AADC protein, human, DDC, EC 4.1.1.28 
Aromatic-L-amino-acid decarboxylase (480 aa, ~54 kDa) is encoded by the human DDC gene. This protein plays a role in the conversion of amino acids to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
We report the results of a long-term follow-up of subjects in a phase 1 study of AAV2-hAADC (adeno-associated virus type 2-human… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND In a primate model of Parkinson disease (PD), intrastriatal infusion of an adeno-associated viral (AAV) vector… (More)
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Highly Cited
2006
Highly Cited
2006
Dopamine, the major neurotransmitter depleted in Parkinson disease, can be synthesized and regulated in vivo with a combination… (More)
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Highly Cited
2006
Highly Cited
2006
Adeno-associated virus type 2 (AAV2)-based vectors are promising transgene carriers for experimental gene therapy treatments of… (More)
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Highly Cited
2005
Highly Cited
2005
To evaluate the consequences of inactivation of the serotonin transporter (SERT) gene on 5-HT homeostasis and function, 5-HT… (More)
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Highly Cited
2003
Highly Cited
2003
We investigated the effect of antisense RNA (asRNA) structural properties on the downregulation efficacy of enzymes in the… (More)
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Highly Cited
2000
Highly Cited
2000
Parkinson's disease (PD), a neurological disease suited to gene therapy, is biochemically characterized by a severe decrease in… (More)
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Highly Cited
1999
Highly Cited
1999
We have studied focal changes in dopaminergic function throughout the brain volume in early and advanced Parkinson's disease by… (More)
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Highly Cited
1990
Highly Cited
1990
In vivo microdialysis was used to examine the effect of L-3,4-dihydroxyphenylalanine (L-DOPA) administration upon dopamine (DA… (More)
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1980
1980
A cell culture line of human small cell (oat cell) carcinoma of the lung (NCI-H69) was studied for growth factor requirements for… (More)
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