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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice,Expand
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Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
Amphetamine (AMPH) inhibits uptake and causes release of dopamine (DA) from presynaptic terminals. AMPH can act on both vesicular storage of DA and directly on the dopamine transporter (DAT). ToExpand
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Profound neuronal plasticity in response to inactivation of the dopamine transporter.
The dopamine transporter (DAT) plays an important role in calibrating the duration and intensity of dopamine neurotransmission in the central nervous system. We have used a strain of mice in whichExpand
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Dopamine Operates as a Subsecond Modulator of Food Seeking
The dopamine projection to the nucleus accumbens has been implicated in behaviors directed toward the acquisition and consumption of natural rewards. The neurochemical studies that established thisExpand
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Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
The ability to predict favorable outcomes using environmental cues is an essential part of learned behavior. Dopamine neurons in the midbrain encode such stimulus-reward relationships in a mannerExpand
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Efflux of dopamine from the synaptic cleft in the nucleus accumbens of the rat brain
Synaptic release of dopamine in the nucleus accumbens of the intact rat brain elicited by a single electrical impulse applied to ascending dopaminergic fibers results in extracellular concentrationsExpand
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Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells.
Secretion of catecholamines from single bovine chromaffin cells in culture was elicited by brief pressure ejections from a micropipette containing nicotine, carbamoylcholine, or potassium ions or byExpand
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Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry
Quantifying mechanisms underlying extracellular signaling by the neurotransmitter dopamine (DA) is a difficult task, particularly in the complex extracellular microenvironment of the intact brain. InExpand
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Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity.
The voltammetric responses of carbon-fiber microelectrodes with a 1.0 V and a 1.4 V anodic limit were compared in this study. Fast-scan cyclic voltammetry was used to characterize the response toExpand
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Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo.
BACKGROUND Dopamine is a potent neuromodulator in the brain, influencing a variety of motivated behaviors and involved in several neurologic diseases. Measurements of extracellular dopamine in theExpand
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