• Publications
  • Influence
Descending control of pain.
  • J. Stamford
  • Medicine
  • British journal of anaesthesia
  • 1 August 1995
Thanks largely to the study of the brainstem nuclei that mediate stimulation analgesia, the involvement of the monoamines in the descending control of pain is now well established. The periaqueductalExpand
Time window of autoreceptor‐mediated inhibition of limbic and striatal dopamine release
Forebrain dopamine release is under the local control of D2 family (D2 and D3) autoreceptors. In this study, autoreceptor‐mediated modulation of forebrain dopamine release was investigated usingExpand
Electrochemical, pharmacological and electrophysiological evidence of rapid dopamine release and removal in the rat caudate nucleus following electrical stimulation of the median forebrain bundle.
Fast cyclic voltammetry was used to monitor the release of electroactive material in the striatum following electrical stimulation of the median forebrain bundle. The released material was shown toExpand
Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus.
Tramadol is an atypical centrally acting analgesic agent with relatively weak opioid receptor affinity in comparison with its antinociceptive efficacy. Evidence suggests that block of monoamineExpand
Development and Ageing of the Rat Nigrostriatal Dopamine System Studied with Fast Cyclic Voltammetry
  • J. Stamford
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1 May 1989
Abstract: Fast cyclic voltammetry at carbon fibre microelectrodes was used to measure electrically stimulated dopamine release in the striatum of anaesthetised young, adult, and senescent WistarExpand
Control of pulsatile 5‐HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics
1 Glucose‐induced insulin release from single islets of Langerhans is pulsatile. We have investigated the correlation between changes in cytosolic free calcium concentration ([Ca2+]i) and oscillatoryExpand
Presynaptic control of striatal dopamine neurotransmission in adult vesicular monoamine transporter 2 (VMAT2) mutant mice
The vesicular monoamine transporter 2 (VMAT2) plays a pivotal role in regulating the size of vesicular and cytosolic dopamine (DA) storage pools within the CNS, and can thus influence extracellularExpand
Control of dorsal raphé 5-HT function by multiple 5-HT1 autoreceptors: parallel purposes or pointless plurality?
The serotonergic cells of the dorsal raphé nucleus innervate much of the forebrain and are thought to be involved in the mechanism of action of antidepressants. Dysfunction of these cells might beExpand
Actions of the hypnotic anaesthetic, dexmedetomidine, on noradrenaline release and cell firing in rat locus coeruleus slices.
We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus.Expand
Evidence that 5‐hydroxytryptamine release in rat dorsal raphé nucleus is controlled by 5‐HT1A, 5‐HT1B and 5‐HT1D autoreceptors
Electrically stimulated 5‐hydroxytryptamine (5‐HT) release was monitored in slices of rat dorsal raphé nucleus (DRN) by fast cylic voltammetry. Pseudo‐single pulse stimulations (5 pulses at 100 Hz)Expand