• Publications
  • Influence
Descending control of pain.
  • J. Stamford
  • Biology
    British journal of anaesthesia
  • 1 August 1995
TLDR
The periaqueductal grey, the raphe nuclei and the locus coeruleus are all key brainstem sites for the control of nociceptive transmission in the spinal cord and it is clear from more recent work that NA has an equally important part to play.
Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus.
TLDR
Activity of (+/-)-tramadol and the (+)-enantiomer, at clinically relevant concentrations, may help to explain the antinociceptive efficacy of tramadol despite weak mu opioid receptor affinity and adds to evidence that tramadl exerts actions on central monoaminergic systems that may contribute to its analgesic effect.
Time window of autoreceptor‐mediated inhibition of limbic and striatal dopamine release
TLDR
Autoreceptor‐mediated modulation of forebrain dopamine release was investigated using amperometry in brain slices following local electrical stimulation and the onset time is due both to diffusion of dopamine from the release sites to the autoreceptors and receptor‐effector mechanisms.
Development and Ageing of the Rat Nigrostriatal Dopamine System Studied with Fast Cyclic Voltammetry
TLDR
The rate of dopamine release was highest in adult rats, and the size of the releasable (newly synthesised) dopamine pool was also largest in the adult group, again with no significant difference occurring between young and aged rats.
Control of pulsatile 5‐HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics
TLDR
In situ 5‐HT microamperometry has the potential to resolve the high‐frequency oscillatory component of the second phase of glucose‐induced insulin secretion, suggesting that glucose metabolism and/or access to glucose metabolites is not rate limiting to fast pulsatile insulin release.
Presynaptic control of striatal dopamine neurotransmission in adult vesicular monoamine transporter 2 (VMAT2) mutant mice
TLDR
It is demonstrated that impaired vesicular DA storage constrains extracellular DA levels in the dorsolateral CPu whether induced by either impulse‐dependent or carrier‐mediated mechanisms and that the relative importance of the DAT and terminal autoreceptors as control mechanisms in the actions of amphetamine are reversed in VMAT2 mutant mice.
Evidence that 5‐hydroxytryptamine release in rat dorsal raphé nucleus is controlled by 5‐HT1A, 5‐HT1B and 5‐HT1D autoreceptors
TLDR
The results suggest that 5‐HT release in the rat DRN is under the control of 5‐ HT1A,5‐HT1B and 5-HT1D autoreceptors.
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