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romidepsin

Known as: N-[(3S,4E-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic, L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-, xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-, L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))- 
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation… 
National Institutes of Health

Related topics

Related topics

15 relations
Angiogenesis InhibitionGene Expression RegulationHistone DeacetylaseNCIt Antineoplastic Agent Terminology

Broader (3)

Antibiotics, AntineoplasticDepsipeptide Antineoplastic AntibioticDepsipeptides

Narrower (4)

FK228FR 901228IstodaxNSC 630176

Papers overview

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1985
1985
Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors.
A new series of thio ester, depsipeptide, and peptide substrates have been synthesized for the bacterial enzyme Clostridium… 
1984
1984
Empedopeptin (BMY-28117), a new depsipeptide antibiotic. II. Structure determination.
Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and… 
1983
1983
Cell-free synthesis of the depsipeptide beauvericin.
The enzymatic formation of the cyclodepsipeptide beauvericin was demonstrated in cell-free extracts from Beauveria bassiana. In… 
1982
1982
Effect of Butylated Hydroxyanisole, α-Angelica Lactone, and β-Naphthoflavone on Benzo(α)pyrene:DNA Adduct Formation in Vivo in the Forestomach, Lung, and Liver of Mice
Abstract The effects of α-angelica lactone (α-AL), butylated hydroxyanisole (BHA), and β-naphthoflavone (β-NF) on the amount of… 
Highly Cited
1980
Highly Cited
1980
Metabolism of cefotaxime in animals and man.
1978
1978
The structure of esterastin, an inhibitor of esterase.
Esterastin (1) is obtained as a colorless powder, mip 99-100•Ž; [ƒ¿]23D+1l•‹ (c 1, CHCI3); UV 265 nm (sh) in 95 % aqueous… 
Highly Cited
1977
Highly Cited
1977
Applications of [2,3]-sigmatropic rearrangements to natural products synthesis. The total synthesis of .+-.-bakkenolide-A (fukinanolide)
A stereoselective total synthesis of the /3-methylene-y-lactone sesquiterpene, bakkenolide-A, is reported. The use of [2,3… 
1977
1977
Sequence specificity of mutagen-nucleic acid complexes in solution: intercalation and mutagen-base pair overlap geometries for proflavine binding to dC-dC-dG-dG and dG-dG-dC-dC self-complementary…
The complex formed between the mutagen proflavine and the dC-dC-dG-dG and dG-dG-dC-dC self-complementary tetranucleotide duplexes… 
1972
1972
Antitumor agents. II. Eupatolide, a new cytotoxic principle from Eupatorium formosanum HAY.
An alcoholic extract of the aboveground parts of Eupatorium formosanum, which showed significant inhibitory activity of the in… 
1966
1966
Blocking by spironolactone (SC 9420) of the action of aldosterone upon the intestinal transport of potassium, sodium, and water.
The action of the adrenal mineralocorticoids upon the intestinal mucosa closely resembles their effect upon the renal tubular…