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romidepsin

Known as: N-[(3S,4E-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic, L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-, xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-, L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))- 
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation… 
National Institutes of Health

Related topics

Related topics

15 relations
Angiogenesis InhibitionGene Expression RegulationHistone DeacetylaseNCIt Antineoplastic Agent Terminology

Broader (3)

Antibiotics, AntineoplasticDepsipeptide Antineoplastic AntibioticDepsipeptides

Narrower (4)

FK228FR 901228IstodaxNSC 630176

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Reactive desorption electrospray ionization linear ion trap mass spectrometry of latest-generation counterfeit antimalarials via noncovalent complex formation.
Desorption electrospray ionization mass spectrometry (DESI MS) is rapidly becoming accepted as a powerful surface… 
Highly Cited
2007
Highly Cited
2007
HDAC inhibitors overcome first hurdle
Despite US marketing approval for the first histone deacetylase inhibitor, these prolific agents still have a lot to prove. 
Highly Cited
2005
Highly Cited
2005
(R)-Goniothalamin: total syntheses and cytotoxic activity against cancer cell lines.
Highly Cited
2001
Highly Cited
2001
Cytotoxic activity of styryl lactones and their derivatives.
  • H. MereyalaM. Joe
  • Current Medicinal Chemistry - Anti-Cancer Agents
  • 2001
  • Corpus ID: 5810047
Many studies that have been conducted to establish the cytotoxic potency of styryl lactones for several tumor cell lines is… 
Highly Cited
1998
Highly Cited
1998
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
PURPOSE To define, in a phase I study in relapsed non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), the… 
Highly Cited
1996
Highly Cited
1996
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.
Hepatitis C virus (HCV) is the major causative agent of non-A non-B hepatitis, an important health problem with an estimated 50… 
Highly Cited
1993
Highly Cited
1993
Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration.
Fuel secretagogues induce hydrolysis of esterified arachidonic acid from pancreatic islet cell phospholipids and accumulation of… 
Highly Cited
1992
Highly Cited
1992
A conformational mechanism for formation of a dead-end complex by the sarcoplasmic reticulum ATPase with thapsigargin.
Highly Cited
1992
Highly Cited
1992
The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate
Vancomycin resistance plasmids in enterococci carry the genes vanH and vanA, which encode enzymes catalyzing, respectively, the… 
Highly Cited
1968
Highly Cited
1968
The Effects of Macrocyclic Compounds on Cation Transport in Sheep Red Cells and Thin and Thick Lipid Membranes
For some years, work in this laboratory has been directed toward elucidation of the mechanism of selectivity of high-potassium… 
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