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romidepsin

Known as: N-[(3S,4E-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic, L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-, xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-, L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))- 
A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation… 
National Institutes of Health

Related topics

Related topics

15 relations
Angiogenesis InhibitionGene Expression RegulationHistone DeacetylaseNCIt Antineoplastic Agent Terminology

Broader (3)

Antibiotics, AntineoplasticDepsipeptide Antineoplastic AntibioticDepsipeptides

Narrower (4)

FK228FR 901228IstodaxNSC 630176

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Different regulation and roles of lactonases AiiB and AttM in Agrobacterium tumefaciens C58.
The phytopathogen Agrobacterium tumefaciens C58 expresses two lactonases, AttM and AiiB. We showed that expression of the aiiB… 
Review
2007
Review
2007
Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.
Echinomycin is the prototypical bisintercalator, a molecule that binds to DNA by inserting two planar chromophores between the… 
Highly Cited
2005
Highly Cited
2005
Enantioselective enol lactone synthesis under double catalytic conditions.
[reaction: see text] The reaction of dimedone with 1-(2-alkenoyl)-4-bromo-3,5-dimethylpyrazoles in THF, catalyzed by catalytic… 
Highly Cited
1997
Highly Cited
1997
SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses.
Highly Cited
1992
Highly Cited
1992
The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate
Vancomycin resistance plasmids in enterococci carry the genes vanH and vanA, which encode enzymes catalyzing, respectively, the… 
Highly Cited
1980
Highly Cited
1980
Metabolism of cefotaxime in animals and man.
Highly Cited
1977
Highly Cited
1977
New methylcyclopentanoid terpenes from the larval defensive secretion of a chrysomelid beetle (Plagiodera versicolora).
The defensive secretion of larvae of the chrysomelid beetle Plagiodera versicolora contains two unstable, volatile… 
Highly Cited
1974
Highly Cited
1974
The regulation of the pentose phosphate cycle in rat liver.
Highly Cited
1968
Highly Cited
1968
The Effects of Macrocyclic Compounds on Cation Transport in Sheep Red Cells and Thin and Thick Lipid Membranes
For some years, work in this laboratory has been directed toward elucidation of the mechanism of selectivity of high-potassium… 
Highly Cited
1944
Highly Cited
1944
Micro-determination of isocitric and cis-aconitic acids in biological material.
oxaloacetate +pyruvate ci 8-acontate = ocitrat. In order to be able to examine the new hypothesis we have worked out methods for… 
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