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Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.
Compounds 1, 3, 12, and 14-16 can serve as new leads for further development of anti-AIDS agents as well as other benzylisoquinoline, aporphine, and bisbenzylisoquoline alkaloids, which were previously isolated from the leaves and embryo of Nelumbo nucifera and evaluated for anti-HIV activity. Expand
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
Calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test, and might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). Expand
Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.
Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells. Expand
Chemical Constituents of Murraya euchrestifolia HAYATA. Structures of Novel Carbazolequinones and Other New Carbazole Alkaloids
Thirteen carbazole alkaloids were isolated from Murraya euchrestifolia HAYATA (Rutaceae) collected in Taiwan. Four of them are novel carbazolequinones [murrayaquinone-A (7), -B (8), -C (9), and -DExpand
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
As a primary screening test for anti-tumor promoters, nine alkaloids isolated from this plant have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Expand
Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii.
The results suggest that these three carbazole alkaloids induced apoptosis in HL-60 cells through activation of the caspase-9/caspases-3 pathway, through mitochondrial dysfunction. Expand
Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity.
All the new xanthones were shown to have a terpenoid (prenyl and/or geranyl) side chain(s) in their molecules. Expand
Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion.
These furanone-coumarins were found to exhibit inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells, the first example of coumarins with these structural characteristics in nature. Expand
In Vitro Absorption and Metabolism of Nobiletin, a Chemopreventive Polymethoxyflavonoid in Citrus Fruits
It is suggested that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro, while that of LT did not. Expand