Histone Deacetylase

Known as: Histone Deacetylases, HDAC Proteins, Deacetylases, Histone 
Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor in adults despite contemporary gold-standard first-line… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
Is this relevant?
Review
2009
Review
2009
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 3
Is this relevant?
Review
2006
Review
2006
Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Histone deacetylases (HDACs) modify core histones and participate in large regulatory complexes that both suppress and enhance… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Review
2001
Review
2001
Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Proteins with expanded polyglutamine repeats cause Huntington's disease and other neurodegenerative diseases. Transcriptional… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?