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Histone Deacetylase

Known as: Histone Deacetylases, HDAC Proteins, Deacetylases, Histone 
Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes… 
Review
2007
Review
2007
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors (HDACi), a group of recently discovered… 
Review
2006
Review
2006
Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic… 
Review
2006
Review
2006
Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and… 
Review
2003
Review
2003
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational… 
Review
2002
Review
2002
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs) allow gene expression to be… 
Highly Cited
2001
Highly Cited
2001
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action… 
Highly Cited
1998
Highly Cited
1998
CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA… 
Highly Cited
1997
Highly Cited
1997
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has… 
Highly Cited
1996
Highly Cited
1996
Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to…