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Histone Deacetylase

Known as: Histone Deacetylases, HDAC Proteins, Deacetylases, Histone 
Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the… 
National Institutes of Health

Related topics

Related topics

41 relations
Chromatin Remodeling FactorDeacetylationEnzyme GeneHDAC7 gene

Narrower (15)

Class I Histone DeacetylasesHDA-1 protein, C elegansHDA6 protein, ArabidopsisHDAC4 protein, Drosophila

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Hepatitis C virus–induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
Chronic hepatitis C is characterized by iron accumulation in the liver, and excessive iron is hepatotoxic. However, the mechanism… 
Review
2008
Review
2008
Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy.
Highly Cited
2006
Highly Cited
2006
Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation.
Osteogenesis is a complex process associated with dramatic changes in gene expression. To elucidate whether modifications in… 
Highly Cited
2006
Highly Cited
2006
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression
Bacterial LPS triggers dramatic changes in gene expression in macrophages. We show here that LPS regulated several members of the… 
Review
2004
Review
2004
Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view.
Modulation of chromatin structure through histone acetylation/deacetylation is known to be one of the major mechanisms involved… 
Highly Cited
2003
Highly Cited
2003
Small Molecule Modulators of Histone Acetyltransferase p300*
Histone acetyltransferases (HATs) are a group of enzymes that play a significant role in the regulation of gene expression. These… 
Highly Cited
2002
Highly Cited
2002
A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
BRAF35, a structural DNA-binding protein, initially was identified as a component of a large BRCA2-containing complex… 
Highly Cited
2001
Highly Cited
2001
The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.
Set3 is one of two proteins in the yeast Saccharomyces cerevisiae that, like Drosophila Trithorax, contains both SET and PHD… 
Highly Cited
2000
Highly Cited
2000
Genomewide studies of histone deacetylase function in yeast.
The trichostatin A (TSA)-sensitive histone deacetylase (HDAC) Rpd3p exists in a complex with Sin3p and Sap30p in yeast that is… 
Highly Cited
1999
Highly Cited
1999
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.
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