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Histone Deacetylase
Known as:
Histone Deacetylases
, HDAC Proteins
, Deacetylases, Histone
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Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the…
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National Institutes of Health
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Related topics
Related topics
41 relations
Chromatin Remodeling Factor
Deacetylation
Enzyme Gene
HDAC7 gene
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Narrower (15)
Class I Histone Deacetylases
HDA-1 protein, C elegans
HDA6 protein, Arabidopsis
HDAC4 protein, Drosophila
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
M. Haberland
,
Rusty L. Montgomery
,
E. Olson
Nature reviews genetics
2009
Corpus ID: 9076396
Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes…
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Review
2007
Review
2007
Histone deacetylase inhibitors: molecular mechanisms of action
Weisheng Xu
,
R. Parmigiani
,
PA Marks
Oncogene
2007
Corpus ID: 23643703
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors (HDACi), a group of recently discovered…
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Review
2006
Review
2006
Anticancer activities of histone deacetylase inhibitors
Jessica E. Bolden
,
M. Peart
,
R. Johnstone
Nature reviews. Drug discovery
2006
Corpus ID: 2857250
Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic…
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Review
2006
Review
2006
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
S. Minucci
,
P. Pelicci
Nature Reviews. Cancer
2006
Corpus ID: 21273047
Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and…
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Review
2003
Review
2003
Histone deacetylases (HDACs): characterization of the classical HDAC family.
Annemieke J M de Ruijter
,
A. V. van Gennip
,
H. Caron
,
S. Kemp
,
A. V. van Kuilenburg
Biochemical Journal
2003
Corpus ID: 6014266
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly influenced by the post-translational…
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Review
2002
Review
2002
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
R. Johnstone
Nature reviews. Drug discovery
2002
Corpus ID: 22567574
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs) allow gene expression to be…
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Highly Cited
2001
Highly Cited
2001
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*
C. Phiel
,
Fang Zhang
,
E. Huang
,
M. Guenther
,
M. Lazar
,
P. S. Klein
Journal of Biological Chemistry
2001
Corpus ID: 35216563
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action…
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Highly Cited
1998
Highly Cited
1998
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Peter L Jones
,
G. Veenstra
,
+5 authors
A. Wolffe
Nature Genetics
1998
Corpus ID: 10426585
CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing. Differences in DNA…
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Highly Cited
1997
Highly Cited
1997
A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression
T. Heinzel
,
R. Lavinsky
,
+12 authors
M. Rosenfeld
Nature
1997
Corpus ID: 4355175
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has…
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Highly Cited
1996
Highly Cited
1996
A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
J. Taunton
,
C. Hassig
,
S. Schreiber
Science
1996
Corpus ID: 25717734
Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to…
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