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Histone Deacetylase

Known as: Histone Deacetylases, HDAC Proteins, Deacetylases, Histone 
Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the… 
National Institutes of Health

Related topics

Related topics

41 relations
Chromatin Remodeling FactorDeacetylationEnzyme GeneHDAC7 gene

Narrower (15)

Class I Histone DeacetylasesHDA-1 protein, C elegansHDA6 protein, ArabidopsisHDAC4 protein, Drosophila

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Sirtuin activators: designing molecules to extend life span.
Highly Cited
2006
Highly Cited
2006
Unexpected deacetylation mechanism suggested by a density functional theory QM/MM study of histone-deacetylase-like protein.
To characterize the catalytic mechanism for zinc-dependent histone deacetylases (HDAC), we have carried out density functional… 
Review
2004
Review
2004
Histone deacetylase inhibitors in clinical development
In addition to a variety of other novel agents, interest in histone deacetylase inhibitors (HDACIs) as antineoplastic drugs has… 
Highly Cited
2004
Highly Cited
2004
DNA Methyltransferase 1 Knock Down Induces Gene Expression by a Mechanism Independent of DNA Methylation and Histone Deacetylation*
DNA methyltransferase 1 (DNMT1) catalyzes the post-replication methylation of DNA and is responsible for maintaining the DNA… 
Highly Cited
2003
Highly Cited
2003
Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.
New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Regulation of the Transforming Growth Factor β Type II Receptor Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y in Human Breast Cancer Cells*
Transcriptional repression of the transforming growth factor-β (TGF-β) type II receptor (TβRII) gene is one of several mechanisms… 
Review
2001
Review
2001
Histone deacetylase: a target for antiproliferative and antiprotozoal agents.
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that influence transcription by selectively… 
Review
2000
Review
2000
Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment.
The role of epigenetic modifications due to deregulated acetylation of nucleosomes with respect to its role in progression and… 
Highly Cited
1998
Highly Cited
1998
Biochemical methods for analysis of histone deacetylases.
Specific lysine residues in the N-terminal extensions of core histones can be posttranslationally modified by acetylation of the… 
Highly Cited
1998
Highly Cited
1998
Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate.
The reversible acetylation of histones by histone deacetylases (HDACs) and acetyltransferases (HATs) plays a fundamental role in… 
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