Deacetylation

Deacetylation is the covalent chemical or post-translational biochemical removal of an acetyl group(s) from organic compounds.
National Institutes of Health

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21 relations
DeacetylaseHDAC1 protein, humanHDAC4 protein, humanHDAC5 protein, human
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Papers overview

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Highly Cited
2010
Highly Cited
2010
SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Sirtuins are NAD-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie… (More)
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Highly Cited
2010
Highly Cited
2010
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor… (More)
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Highly Cited
2010
Highly Cited
2010
Human SIRT6 promotes DNA end resection through CtIP deacetylation.
SIRT6 belongs to the sirtuin family of protein lysine deacetylases, which regulate aging and genome stability. We found that… (More)
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Highly Cited
2009
Highly Cited
2009
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of… (More)
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Highly Cited
2008
Highly Cited
2008
SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus of the brain that… (More)
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Review
2007
Review
2007
Functions of site-specific histone acetylation and deacetylation.
Histone acetylation regulates many cellular processes, and specific acetylation marks, either singly or in combination, produce… (More)
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Highly Cited
2006
Highly Cited
2006
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic inflammatory diseases even though… (More)
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Highly Cited
2005
Highly Cited
2005
Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription
Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3… (More)
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Highly Cited
2003
Highly Cited
2003
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast… (More)
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Highly Cited
2002
Highly Cited
2002
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
Trichostatin A (TSA) inhibits all histone deacetylases (HDACs) of both class I and II, whereas trapoxin (TPX) cannot inhibit… (More)
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