HDAC1 protein, human

Known as: RPD3L1 protein, human, histone deacetylase 1, human, Histone Deacetylase 1 
Histone deacetylase 1 (482 aa, ~55 kDa) is encoded by the human HDAC1 gene. This protein is involved in chromatin remodeling and the negative… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Defects in DNA repair have been extensively linked to neurodegenerative diseases, but the exact mechanisms remain poorly… (More)
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Highly Cited
2012
Highly Cited
2012
Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases… (More)
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Highly Cited
2010
Highly Cited
2010
DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by chromatin-modifying enzymes. Here we… (More)
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Highly Cited
2010
Highly Cited
2010
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structure as the core catalytic… (More)
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Highly Cited
2008
Highly Cited
2008
Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in various neurodegenerative… (More)
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Highly Cited
2005
Highly Cited
2005
Estrogen is well-established as a mitogenic factor implicated in the tumorigenesis and progression of breast cancer via its… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Histone deacetylase 1 (HDAC1) is a co-repressor involved in differentiation and proliferation control. It is… (More)
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Highly Cited
2002
Highly Cited
2002
The tumor suppressor p53 is stabilized and activated in response to cellular stress through post-translational modifications… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of NF-kappaB transactivation function is controlled at several levels, including interactions with coactivator… (More)
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Highly Cited
1998
Highly Cited
1998
Treatment of mammalian cells with small molecule histone deacetylase (HDAC) inhibitors induces changes in the transcription of… (More)
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