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Measuring In Vivo Mitophagy.
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse… Expand
Acetylcholinesterase plays a pivotal role in apoptosome formation.
Although a recent study (Zhang et al. Cell Death Differ 2002; 9; 790-800) presented that acetylcholinesterase (AChE) might be an important common component in leading to various types of apoptosis,… Expand
Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3.
Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower. Its inhibitory effects on tumor cell growth in vitro… Expand
Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary
- Seung Gee Lee, J. Kim, +7 authors J. Kim
- Medicine, Biology
- Environmental health perspectives
- 19 March 2013
Background: Bisphenol A (BPA) has been detected in human body fluids, such as serum and ovarian follicular fluids. Several reports indicated that BPA exposure is associated with the occurrence of… Expand
Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells.
- J. Jeong, Cheng-yun Jin, +6 authors Y. Choi
- Biology, Medicine
- Toxicology in vitro : an international journal…
- 1 June 2011
Cordycepin (3'-deoxyadenosin), a specific polyadenylation inhibitor, is the main functional component in Cordyceps militaris, one of the top three renowned traditional Chinese medicines. Cordycepin… Expand
Redox factor‐1 mediates NF‐κB nuclear translocation for LPS‐induced iNOS expression in murine macrophage cell line RAW 264.7
Redox‐sensitive transcriptional regulator redox factor‐1 (Ref‐1) is induced by oxidative stress and protects cells against it. However, the function of Ref‐1 in regulating nitric oxide (NO) synthesis… Expand
Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis
Our previous studies demonstrated that antiallergic effects of herbs such as clove and Magnoliae Flos (MF) resulted from the induction of apoptosis in mast cells. We here examined whether the… Expand
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells.
We have compared the anti-proliferative effects of ursodeoxycholic acid (UDCA), chenodeoxycholic acid (CDCA) and their derivatives, HS-1183, HS-1199 and HS-1200, on MCF-7 (wild-type p53) and… Expand
Benzo[a]pyrene Reduces Testosterone Production in Rat Leydig Cells via a Direct Disturbance of Testicular Steroidogenic Machinery
Background: Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is a ubiquitous environmental pollutant that is currently suspected of being an endocrine disruptor. The testis is an… Expand
Interleukin‐6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration
- H. Lee, In Ae Seo, D. J. Suh, Jeong-In Hong, Y. Yoo, H. Park
- Medicine, Biology
- Journal of neurochemistry
- 1 February 2009
Signal transducer and activator of transcription 3 (STAT3) regulates gene transcription in response to cytokines and growth factors. In the central nervous system, STAT3 plays a role in… Expand