Deacetylase

An enzyme that hydrolyzes N-acetyl groups.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Heat shock factor 1 (HSF1) is essential for protecting cells from protein-damaging stress associated with misfolded proteins and… (More)
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Highly Cited
2009
Highly Cited
2009
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression… (More)
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Highly Cited
2009
Highly Cited
2009
To survive in hostile environments, organisms activate stress-responsive transcriptional regulators that coordinately increase… (More)
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Highly Cited
2009
Highly Cited
2009
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses… (More)
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Highly Cited
2008
Highly Cited
2008
We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased… (More)
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Highly Cited
2008
Highly Cited
2008
Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance of basal ATP levels and as a… (More)
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Highly Cited
2008
Highly Cited
2008
There are seven SIRT isoforms in mammals, with diverse biological functions including gene regulation, metabolism, and apoptosis… (More)
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Highly Cited
2007
Highly Cited
2007
A progressive loss of neurons with age underlies a variety of debilitating neurological disorders, including Alzheimer's disease… (More)
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Highly Cited
2006
Highly Cited
2006
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether… (More)
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Highly Cited
2004
Highly Cited
2004
A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR… (More)
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