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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
TLDR
A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
View on Nature
Leptin-regulated endocannabinoids are involved in maintaining food intake
TLDR
It is shown that following temporary food restriction, CB1 receptor knockout mice eat less than their wild-type littermates, and the CB1 antagonist SR141716A reduces food intake in wild- type but not knockout mice, which indicates that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.
View on Nature
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene.
TLDR
It is shown that histochemically reactive zinc, corresponding to the zinc found within synaptic vesicles, was undetectable in the brains of mice with targeted disruption of the ZnT3 gene, and it is suggested that vesicular zinc concentration is determined by the abundance of ZNT3.
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Noradrenaline is essential for mouse fetal development
TLDR
It is reported here that in heterozygous mothers, most homozygous embryos died in utero, and only about 5% reached adulthood, suggesting that death might be due to cardiovascular failure.
View on Nature
ZnT-3, a putative transporter of zinc into synaptic vesicles.
TLDR
It is proposed that ZnT-3 facilitates the accumulation of zinc in synaptic vesicles, which is most abundant in the hippocampus and cerebral cortex and is similar to that obtained with Timm's reaction.
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Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport
TLDR
It is found that in the genetic disease Niemann–Pick type C and in drug-treated cells that mimic NPC, cholesterol accumulates in late endosomes and sorting of the lysosomal enzyme receptor is impaired.
View on Nature
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
TLDR
It is suggested that network-based compensatory mechanisms can develop after the ablation of NPY/AgRP neurons in neonates but do not readily occur when these neurons become essential in adults.
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Vesicular Glutamate Transport Promotes Dopamine Storage and Glutamate Corelease In Vivo
View on Elsevier
Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.
TLDR
It is proposed that ZnT‐1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity.
View on Wiley
Genetic identification of a neural circuit that suppresses appetite
TLDR
Genetically encoded anatomical, optogenetic and pharmacogenetic tools are demonstrated that activation of neurons projecting to the central nucleus of the amygdala suppresses appetite and inhibition of these neurons increases food intake in circumstances when mice do not normally eat and prevents starvation in adult mice whose agouti-related peptide neurons are ablated.
View on Nature
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