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Epigenetic programming by maternal behavior
Here we report that increased pup licking and grooming (LG) and arched-back nursing (ABN) by rat mothers altered the offspring epigenome at a glucocorticoid receptor (GR) gene promoter in theExpand
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stressExpand
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Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life
Stress responses in the adult rat are programmed early in life by maternal care and associated with epigenomic marking of the hippocampal exon 17 glucocorticoid receptor (GR) promoter. To examineExpand
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Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.
Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight,Expand
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Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
  • M. Meaney, M. Szyf
  • Biology, Medicine
  • Dialogues in clinical neuroscience
  • 1 June 2005
Early experience permanently alters behavior and physiology. These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. The critical question concernsExpand
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Maternal care as a model for experience-dependent chromatin plasticity?
It is widely acknowledged that the nature of the maternal care a child receives can have long-term repercussions, and that children raised in deprived environments can have severe cognitive andExpand
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The Transcription Factor Nerve Growth Factor-Inducible Protein A Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes
Maternal care alters epigenetic programming of glucocorticoid receptor (GR) gene expression in the hippocampus, and increased postnatal maternal licking/grooming (LG) behavior enhances nerve growthExpand
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Epigenetics, DNA methylation, and chromatin modifying drugs.
  • M. Szyf
  • Medicine, Biology
  • Annual review of pharmacology and toxicology
  • 25 March 2009
Evidence is emerging that several diseases and behavioral pathologies result from defects in gene function. The best-studied example is cancer, but other diseases such as autoimmune disease, asthma,Expand
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A mammalian protein with specific demethylase activity for mCpG DNA
DNA-methylation patterns are important for regulating genome functions, and are determined by the enzymatic processes of methylation and demethylation. The demethylating enzyme has now beenExpand
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Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring
Variations in maternal behavior are associated with differences in estrogen receptor (ER)-α expression in the medial preoptic area (MPOA) and are transmitted across generations such that, as adults,Expand
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