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FR 901228
Known as:
Antibiotic FR 901228
, FR-901228
, FR901228
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Depsipeptides
romidepsin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down…
J. L. Aron
,
M. Parthun
,
+11 authors
J. Byrd
Blood
2003
Corpus ID: 15864708
Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating…
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Review
2003
Review
2003
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.
Wei-Guo Zhu
,
G. Otterson
Current medicinal chemistry. Anti-cancer agents
2003
Corpus ID: 31079958
The potential anticancer activities of histone deacetylase (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors have…
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Highly Cited
2002
Highly Cited
2002
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
M. Blagosklonny
,
R. Robey
,
+5 authors
S. Bates
Molecular cancer therapeutics
2002
Corpus ID: 19629049
By preventing deacetylation of histones, histone deacetylase inhibitors (HDIs) transcriptionally induce p21. Here we show that…
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Highly Cited
2002
Highly Cited
2002
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.
J. Marshall
,
N. Rizvi
,
+8 authors
M. Hawkins
Journal of experimental therapeutics & oncology
2002
Corpus ID: 36148695
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro…
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Highly Cited
2001
Highly Cited
2001
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.
R. Piekarz
,
R. Robey
,
+7 authors
S. Bates
Blood
2001
Corpus ID: 376619
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines…
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Review
2001
Review
2001
Histone deacetylase as a new target for cancer chemotherapy
Minoru Yoshida
,
R. Furumai
,
M. Nishiyama
,
Y. Komatsu
,
N. Nishino
,
S. Horinouchi
Cancer Chemotherapy and Pharmacology
2001
Corpus ID: 8955178
Abstract. Trichostatin A (TSA) and trapoxin (TPX), inhibitors of the eukaryotic cell cycle and inducers of morphological…
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Highly Cited
2000
Highly Cited
2000
P21-dependent G 1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
V. Sandor
,
A. Senderowicz
,
+4 authors
S. Bates
British Journal of Cancer
2000
Corpus ID: 18462574
Depsipeptide, FR901228, a novel cyclic peptide inhibitor of histone deacetylase with a unique cytotoxicity profile is currently…
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Highly Cited
1998
Highly Cited
1998
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.
H. Nakajima
,
Y. B. Kim
,
H. Terano
,
M. Yoshida
,
S. Horinouchi
Experimental cell research
1998
Corpus ID: 6304146
Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of…
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor…
H. Ueda
,
H. Nakajima
,
+4 authors
M. Okuhara
The Journal of antibiotics
1994
Corpus ID: 43667851
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as…
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Highly Cited
1994
Highly Cited
1994
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.
H. Ueda
,
H. Nakajima
,
Y. Hori
,
T. Goto
,
M. Okuhara
Bioscience, biotechnology, and biochemistry
1994
Corpus ID: 11722722
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and…
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