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FR 901228

Known as: Antibiotic FR 901228, FR-901228, FR901228 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
ABSTRACT Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here… 
Highly Cited
2003
Highly Cited
2003
Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating… 
Highly Cited
2002
Highly Cited
2002
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro… 
Highly Cited
2002
Highly Cited
2002
By preventing deacetylation of histones, histone deacetylase inhibitors (HDIs) transcriptionally induce p21. Here we show that… 
Highly Cited
2001
Highly Cited
2001
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines… 
Highly Cited
1999
Highly Cited
1999
Oxamflatin [(2E) - 5 - [3 - [(phenylsufonyl) amino] phenyl]-pent-2-en-4-ynohydroxamic acid] induces transcriptional activation of… 
Highly Cited
1998
Highly Cited
1998
Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of… 
Highly Cited
1994
Highly Cited
1994
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as… 
Highly Cited
1994
Highly Cited
1994
The antitumor activities of FR901228, (E)-(1S,4S,10S,21R)-7-[(Z)- ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23… 
Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and…