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FR 901228

Known as: Antibiotic FR 901228, FR-901228, FR901228 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
ABSTRACT Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here… Expand
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Highly Cited
2003
Highly Cited
2003
Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating… Expand
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Highly Cited
2002
Highly Cited
2002
By preventing deacetylation of histones, histone deacetylase inhibitors (HDIs) transcriptionally induce p21. Here we show that… Expand
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Highly Cited
2002
Highly Cited
2002
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro… Expand
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Highly Cited
2001
Highly Cited
2001
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines… Expand
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Highly Cited
2000
Highly Cited
2000
Depsipeptide, FR901228, a novel cyclic peptide inhibitor of histone deacetylase with a unique cytotoxicity profile is currently… Expand
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Highly Cited
1999
Highly Cited
1999
Oxamflatin [(2E) - 5 - [3 - [(phenylsufonyl) amino] phenyl]-pent-2-en-4-ynohydroxamic acid] induces transcriptional activation of… Expand
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Highly Cited
1998
Highly Cited
1998
Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of… Expand
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Highly Cited
1994
Highly Cited
1994
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as… Expand
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and… Expand
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