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FR 901228
Known as:
Antibiotic FR 901228
, FR-901228
, FR901228
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Depsipeptides
romidepsin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1
Ying Zhao
,
Shaoli Lu
,
+10 authors
Wei-Guo Zhu
Molecular and Cellular Biology
2006
Corpus ID: 23880192
ABSTRACT Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here…
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Highly Cited
2003
Highly Cited
2003
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down…
J. L. Aron
,
M. Parthun
,
+11 authors
J. Byrd
Blood
2003
Corpus ID: 15864708
Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating…
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Highly Cited
2002
Highly Cited
2002
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.
J. Marshall
,
N. Rizvi
,
+8 authors
M. Hawkins
Journal of experimental therapeutics and oncology
2002
Corpus ID: 36148695
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro…
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Highly Cited
2002
Highly Cited
2002
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
M. Blagosklonny
,
R. Robey
,
+5 authors
S. Bates
Molecular Cancer Therapeutics
2002
Corpus ID: 19629049
By preventing deacetylation of histones, histone deacetylase inhibitors (HDIs) transcriptionally induce p21. Here we show that…
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Highly Cited
2001
Highly Cited
2001
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.
R. Piekarz
,
R. Robey
,
+7 authors
S. Bates
Blood
2001
Corpus ID: 376619
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines…
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Highly Cited
1999
Highly Cited
1999
Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
Young Bae Kim
,
Kun-Hyung Lee
,
K. Sugita
,
Minoru Yoshida
,
S. Horinouchi
Oncogene
1999
Corpus ID: 20515946
Oxamflatin [(2E) - 5 - [3 - [(phenylsufonyl) amino] phenyl]-pent-2-en-4-ynohydroxamic acid] induces transcriptional activation of…
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Highly Cited
1998
Highly Cited
1998
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.
H. Nakajima
,
Y. B. Kim
,
H. Terano
,
M. Yoshida
,
S. Horinouchi
Experimental Cell Research
1998
Corpus ID: 6304146
Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of…
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor…
H. Ueda
,
H. Nakajima
,
+4 authors
M. Okuhara
Journal of antibiotics (Tokyo. )
1994
Corpus ID: 43667851
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as…
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Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
H. Ueda
,
T. Manda
,
+4 authors
K. Shimomura
Journal of antibiotics (Tokyo. )
1994
Corpus ID: 27826551
The antitumor activities of FR901228, (E)-(1S,4S,10S,21R)-7-[(Z)- ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23…
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Highly Cited
1994
Highly Cited
1994
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.
H. Ueda
,
H. Nakajima
,
Y. Hori
,
T. Goto
,
M. Okuhara
Bioscience, biotechnology and biochemistry
1994
Corpus ID: 11722722
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and…
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