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FR 901228

Known as: Antibiotic FR 901228, FR-901228, FR901228 
National Institutes of Health

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2 relations

Broader (2)

Depsipeptidesromidepsin

Papers overview

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2009
2009
Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction
PurposeReveal mechanisms for the novel proapoptotic ability of oncogenic H-Ras to increase cell susceptibility to a histone… 
2007
2007
Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells
More than 35% of human urinary bladder cancers involve oncogenic H-Ras activation. In addition to tumorigenic ability, oncogenic… 
2007
2007
The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems
A major limitation of adenovirus type 5–mediated cancer gene therapy is the inefficient infection of many cancer cells… 
Highly Cited
2005
Highly Cited
2005
Histone deacetylase inhibitors differentially mediate apoptosis in prostate cancer cells
Histone deacetylase (HDAC) inhibitors have shown significant anti‐proliferative and apoptotic properties on various cancer cells… 
Highly Cited
2005
Highly Cited
2005
Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor.
2004
2004
Effects of demethylating agent 5-aza-2(')-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines.
Highly Cited
2004
Highly Cited
2004
The histone deacetylase inhibitor FR901228 induces caspase-dependent apoptosis via the mitochondrial pathway in small cell lung cancer cells.
Histone deacetylase inhibitors modulate the transcription of target genes and represent a new class of anticancer agents. The… 
2004
2004
Depsipeptide (FR901228, NSC-630176) pharmacokinetics in the rat by LC/MS/MS
Depsipeptide, a cyclic peptide (FR), isolated from Chrombacterium violaceum strain WB968 by Fujisawa Company during a screening… 
2002
2002
Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228.
(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9… 
2002
2002
The Histone Deacetylase Inhibitor FR901228 (Depsipeptide) Restores Expression and Function of Pseudo-Null p53
We have previously described a novel mechanism of p53 dysfunction, characterized by repression of mRNA and protein expression… 
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