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FR 901228

Known as: Antibiotic FR 901228, FR-901228, FR901228 
National Institutes of Health

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2 relations

Broader (2)

Depsipeptidesromidepsin

Papers overview

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Highly Cited
2006
Highly Cited
2006
Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1
ABSTRACT Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here… 
Highly Cited
2003
Highly Cited
2003
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down…
Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating… 
Highly Cited
2002
Highly Cited
2002
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro… 
Highly Cited
2002
Highly Cited
2002
Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.
By preventing deacetylation of histones, histone deacetylase inhibitors (HDIs) transcriptionally induce p21. Here we show that… 
Highly Cited
2001
Highly Cited
2001
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines… 
Highly Cited
1999
Highly Cited
1999
Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
Oxamflatin [(2E) - 5 - [3 - [(phenylsufonyl) amino] phenyl]-pent-2-en-4-ynohydroxamic acid] induces transcriptional activation of… 
Highly Cited
1998
Highly Cited
1998
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.
Screening for microbial metabolites that induce transcriptional activation of the SV40 promoter resulted in the identification of… 
Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor…
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as… 
Highly Cited
1994
Highly Cited
1994
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice.
The antitumor activities of FR901228, (E)-(1S,4S,10S,21R)-7-[(Z)- ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23… 
Highly Cited
1994
Highly Cited
1994
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and… 
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