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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
TLDR
A large number of the subjects studied had previously been diagnosed with central giant cell granuloma, a type of cancer which can be difficult to treat with conventional chemotherapy. Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
TLDR
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed. Expand
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
TLDR
A functional classification of cell death subroutines is proposed that applies to both in vitro and in vivo settings and includes extrinsic apoptosis, caspase-dependent or -independent intrinsic programmed cell death, regulated necrosis, autophagic cell death and mitotic catastrophe. Expand
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
TLDR
The Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death. Expand
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
TLDR
This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including ‘entosis’, ‘mitotic catastrophe”,’ ‘necrosis‚ ‘necroptosis‚’ and ‘pyroptotic’. Expand
Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association (*)
TLDR
Using this drug, it is able to demonstrate rapid dissociation of both Raf-1-Hsp90 and Raf- 1-Ras multimolecular complexes, concomitant with a markedly decreased half-life of the Raf-2 protein. Expand
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
TLDR
The results suggest that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its association with HIF-1α. Expand
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
TLDR
A nonexhaustive comparison of methods to detect cell death with apoptotic or nonapoptotic morphologies, their advantages and pitfalls is provided and the importance of performing multiple, methodologically unrelated assays to quantify dying and dead cells is emphasized. Expand
Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition
TLDR
Theoretical and clinical considerations suggest that rapamycin may be effective against atherosclerosis, hypertension and hyper-coagulation, and extended life span will reveal new causes for aging that play a limited role now, when quasi-programmed senescence kills us first. Expand
The Restriction Point of the Cell Cycle
TLDR
The relationship between the restriction knot and DNA damage-checkpoints is discussed, and how loss of the restriction point in cancer leads to loss of checkpoint control and to insensitivity to antimitogens including some mechanism-based anticancer therapeutics. Expand
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