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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan
TLDR
This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan, which indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China.
Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study
TLDR
Precise assessment of curability with successful one-piece resection may reduce tumour recurrence after ESD, and the prognosis of EGC patients treated by ESD is likely to be excellent, though further longer follow-up studies are warranted.
Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.
TLDR
Data indicate that BCRP is directly involved with SN-38 resistance, by efflux transport of SN-37 and antisense oligonucleotides significantly suppressed B CRP mRNA expression, and enhancedSN-38 sensitivity in the subline.
The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis
TLDR
Evidence is provided suggesting that RNI play a role in regulating M. tuberculosis gene expression in vivo and RNI and hypoxia may regulate mycobacterial gene expression via overlapping signal transduction pathways.
Gefitinib ("Iressa", ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, reverses breast cancer resistance protein/ABCG2-mediated drug resistance.
TLDR
Results indicate that gefitinib reverses B CRP-mediated drug resistance by direct inhibition other than competitive inhibition as a BCRP substrate, and Combination of gef itinib and topoisomerase I inhibitors could be clinically effective in cancers expressing BCRp.
A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis.
TLDR
The number of neutrophils in the peripheral blood was not affected by erythromycin, indicating that the drug was not toxic, and there was a significant correlation between the reduction of NCA and neutrophil percentage in pre- and post-eryhromycin treatment BALF.
Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida albicans strains.
TLDR
The data suggest that measurement of intracellular accumulation of R6G is a useful method for identification of azole-resistant strains due to CDR1-expressed drug efflux pump.
International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections.
Because of the rapidly increasing incidence of serious candidal infections, a consensus conference of 22 investigators from the United States, Europe, and Japan was held to discuss strategies for the
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