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Multidrug resistance in cancer: role of ATP–dependent transporters
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become simultaneously resistant to different drugs — a trait known as multidrug… Expand
The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2).
Mechanisms of drug resistance other than P-glycoprotein are of increasing interest as the list of newly identified members of the ABC transport family has grown. We sought to characterize the… Expand
The role of ABC transporters in clinical practice.
Drug resistance remains one of the primary causes of suboptimal outcomes in cancer therapy. ATP-binding cassette (ABC) transporters are a family of transporter proteins that contribute to drug… Expand
Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity
- R. Robey, Yasumasa Honjo, +5 authors S. Bates
- Medicine, Biology
- British Journal of Cancer
- 11 November 2003
Recent studies have shown that mutations at amino-acid 482 in the ABCG2 gene affect the substrate specificity of the protein. To delineate the effects of these mutations clearly, human embryonic… Expand
From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance
- T. Litman, T. Druley, W. Stein, S. Bates
- Biology, Medicine
- Cellular and Molecular Life Sciences CMLS
- 1 June 2001
Abstract: The ATP binding cassette (ABC) superfamily of membrane transporters is one of the largest protein classes known, and counts numerous proteins involved in the trafficking of biological… Expand
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.
- R. Piekarz, R. Frye, +17 authors S. Bates
- Journal of clinical oncology : official journal…
- 10 November 2009
PURPOSE Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic agents active in T-cell lymphoma, the histone deacetylase inhibitors. On the basis of observed responses in a… Expand
ABCG2: determining its relevance in clinical drug resistance
- R. Robey, O. Polgar, J. Deeken, K. W. To, S. Bates
- Medicine, Biology
- Cancer and Metastasis Reviews
- 24 February 2007
Multidrug resistance is a major obstacle to successful cancer treatment. One mechanism by which cells can become resistant to chemotherapy is the expression of ABC transporters that use the energy of… Expand
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
A disparity was noted in the transport of rhodamine 123 among nine MXR/BCRP/ABCP-overexpressing cells studied; all demonstrated mitoxantrone transport, whereas only two effluxed rhodamine 123. When… Expand
Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.
ABCG2 is a plasma membrane efflux pump that is able to confer resistance to several anticancer agents, including mitoxantrone, camptothecins, anthracyclines, and flavopiridol. The antimetabolite… Expand
Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor
P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype in cancer. Tariquidar is a potent, specific, noncompetitive inhibitor… Expand