FK228
National Institutes of Health
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Novel structural analogues of a HDAC inhibitor FK228 have been synthesized by modifying the most synthetically challenging unit…
Background:Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which…
Resistance to imatinib can occur in patients with chronic myelogenous leukemia (CML). In this study, we report mechanisms of…
A major limitation of adenovirus type 5–mediated cancer gene therapy is the inefficient infection of many cancer cells…
Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly…
A novel histone deacetylase inhibitor, FK228, is a promising anticancer agent and has been proposed to modulate intracellular…
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic…