FK228

 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Romidepsin (depsipeptide or FK228) is a histone deacetylase inhibitor, one of a new class of agents active in T-cell lymphoma. A… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Romidepsin (depsipeptide or FK228) is a member of a new class of antineoplastic agents active in T-cell lymphoma, the… (More)
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Highly Cited
2006
Highly Cited
2006
Histone deacetylase (HDAC) inhibitors modify transcription of selected genes and eventually induce apoptosis. However, molecular… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE The histone deacetylase inhibitor depsipeptide (FK228) has activity in patients with cutaneous or peripheral T-cell… (More)
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2005
2005
About 97% of synovial sarcomas harbor the SYT-SSX fusion gene by chromosomal translocation. We found that the histone deacetylase… (More)
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2005
2005
PURPOSE The histone deacetylase inhibitor FK228 shows strong activity as a potent antitumor drug but its precise mechanism is… (More)
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Highly Cited
2004
Highly Cited
2004
Preclinical studies with the histone deacetylase (HDAC) inhibitor depsipeptide (FK228) in chronic lymphocytic leukemia (CLL) and… (More)
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Highly Cited
2002
Highly Cited
2002
FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanism of inhibition of which has been unknown. Here we show… (More)
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Highly Cited
2002
Highly Cited
2002
FK228 (formerly FR901228) was recently isolated from Chromobacterium violaceum as a potent antitumor agent and its biologic… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Histone deacetylases (HDACs) modulate chromatin structure by regulating acetylation of core histone proteins. HDAC… (More)
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