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FK228

National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
ABSTRACT A gene cluster responsible for the biosynthesis of anticancer agent FK228 has been identified, cloned, and partially… 
2007
2007
Background:Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which… 
2007
2007
Resistance to imatinib can occur in patients with chronic myelogenous leukemia (CML). In this study, we report mechanisms of… 
2007
2007
Histone deacetylase inhibitors (HDACIs) are promising therapeutic agents with the potential for regulating cell cycle… 
Highly Cited
2005
Highly Cited
2005
Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly… 
2005
2005
A novel histone deacetylase inhibitor, FK228, is a promising anticancer agent and has been proposed to modulate intracellular… 
Highly Cited
2004
Highly Cited
2004
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic…