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FK228

National Institutes of Health

Papers overview

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2008
2008
Novel structural analogues of a HDAC inhibitor FK228 have been synthesized by modifying the most synthetically challenging unit… 
2007
2007
Background:Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which… 
2007
2007
Resistance to imatinib can occur in patients with chronic myelogenous leukemia (CML). In this study, we report mechanisms of… 
2007
2007
A major limitation of adenovirus type 5–mediated cancer gene therapy is the inefficient infection of many cancer cells… 
Highly Cited
2005
Highly Cited
2005
Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly… 
2005
2005
A novel histone deacetylase inhibitor, FK228, is a promising anticancer agent and has been proposed to modulate intracellular… 
Highly Cited
2004
Highly Cited
2004
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic…