FK228
National Institutes of Health
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ABSTRACT A gene cluster responsible for the biosynthesis of anticancer agent FK228 has been identified, cloned, and partially…
Background:Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which…
Resistance to imatinib can occur in patients with chronic myelogenous leukemia (CML). In this study, we report mechanisms of…
Histone deacetylase inhibitors (HDACIs) are promising therapeutic agents with the potential for regulating cell cycle…
Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly…
A novel histone deacetylase inhibitor, FK228, is a promising anticancer agent and has been proposed to modulate intracellular…
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic…