FK228
National Institutes of Health
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SUMMARY:
Establishing a stable covalent bond between proteins and nucleic acids, usually
referred to as crosslinking is a…
The aim of this study was to investigate the anti-tumor activity of KBH-A42, a novel synthetic histone deacetylase (HDAC…
Previous studies have shown that histone deacetylase inhibitors (HDACis) can kill cancer cells. In addition, HDACis can induce…
Unique chimeric mitochondrial genes are associated with cytoplasmic male sterility (CMS) in many higher plants. It is thought…
Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis…
The present invention, HDAC inhibitors derivatives, in particular derivatives of free thiol metabolite of HDAC inhibitors FK228…
Analogues de FK228 et methodes de production et d'utilisation desdits analogues. Ces analogues sont de puissants inhibiteurs de l…
FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanism of inhibition of which has been unknown. Here we show…
L'invention porte sur FK228 reduit represente par la formule generale (I) ou des sels de celui-ci, sur des inhibiteurs de l…