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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular etiology and cellular origin are unknown. Sequencing of c-kit… Expand
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.
BACKGROUND & AIMS Most gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of c-kit receptor tyrosine kinase (KIT) gene, but some GISTs do not. We investigated the cause of GISTs… Expand
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Background: Mikulicz’s disease (MD) has been considered as one manifestation of Sjögren’s syndrome (SS). Recently, it has also been considered as an IgG4-related disorder. Objective: To determine the… Expand
Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis
- Masanori Ii, H. Yamamoto, Y. Adachi, Y. Maruyama, Y. Shinomura
- Biology, Medicine
- Experimental biology and medicine
- 1 January 2006
Matrix metalloproteinase (MMP)-7, also known as matrilysin, is a “minimal domain MMP” that exhibits proteolytic activity against components of the extracellular matrix (ECM). Matrilysin is frequently… Expand
A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease
Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but it represents a unique condition involving persistent enlargement of the lacrimal and salivary… Expand
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
BACKGROUND & AIMS Obesity is one of the risk factors for liver fibrosis, in which plasma adiponectin, an adipocytokine, levels are decreased. Hepatic stellate cells play central roles in liver… Expand
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway
- Miki Ito, Shinichi Kanno, +17 authors Y. Shinomura
- International journal of cancer
- 1 September 2015
Human gut microbiota is being increasingly recognized as a player in colorectal cancers (CRCs). Evidence suggests that Fusobacterium nucleatum (F. nucleatum) may contribute to disease progression and… Expand
Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis
Recently, bacterial infection causing periodontal disease has attracted considerable attention as a risk factor for pancreatic cancer. Fusobacterium species is an oral bacterial group of the human… Expand
Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.
Large intergenic noncoding RNAs (lincRNA) have been less studied than miRNAs in cancer, although both offer considerable theranostic potential. In this study, we identified frequent upregulation of… Expand
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis
Background—The pathogenesis of ulcerative colitis is unclear, but cytotoxic T lymphocytes infiltrating the mucosa have been implicated in mucosal damage. The Fas ligand (FasL), expressed on cytotoxic… Expand