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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development. Expand
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.
The gain-of-function mutations of PDGFR alpha appear to play an important role in development of GISTs without KIT mutations. Expand
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
The results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR/c CpG island, which bidirectionally regulates miR’s 34b-34c and 4B-cell translocation gene 4, is a frequent target of epigenetic silencing in CRC. Expand
Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis
- Masanori Ii, Hiroyuki Yamamoto, Y. Adachi, Y. Maruyama, Y. Shinomura
- Chemistry, Medicine
- Experimental biology and medicine
- 1 January 2006
It is proposed that these matrilysin-mediated pathways provide the necessary and logical mechanisms to promote cancer progression. Expand
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
There are considerable clinical and pathological differences between IgG4+MOLPS and SS, and based on the clinical features and good response to glucocorticoids, a new clinical entity is proposed: IgG 4+MolPS. Expand
A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease
Mikulicz's disease represents a unique condition involving persistent enlargement of the lacrimal and salivary glands characterized by few autoimmune reactions and good responsiveness to glucocorticoids, leading to the recovery of gland function. Expand
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
- H. Suzuki, M. Toyota, +13 authors T. Tokino
- Biology, Medicine
- British Journal of Cancer
- 19 February 2008
The results confirm the frequent methylation and silencing of Wnt antagonist genes in breast cancer, and suggest that their loss of function contributes to activated Wnt signalling in breast carcinogenesis. Expand
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway
The presence of F. nucleatum was identified in premalignant colorectal lesions regardless of histopathology but was more frequently associated with CIMP‐high lesions, and its positivity increased according to histological grade, suggesting that it may contribute to the progression of coloreCTal neoplasia. Expand
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
The findings indicate that adiponectin attenuates liver fibrosis and could be a novel approach in its prevention. Expand
Absence of c‐kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients
- K. Kinoshita, S. Hirota, +5 authors Y. Matsuzawa
- Biology, Medicine
- The Journal of pathology
- 1 January 2004
The results suggest that the pathogenesis of GISTs in NF1 patients is different from that in non‐NF1 patients. Expand