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Apaf-1 Is a Mediator of E2F-1-induced Apoptosis*
A novel mechanism of apoptosis is demonstrated in which an increase in Apaf-1 levels results in direct activation of caspase-9 without mitochondrial damage, leading to the initiation of a casp enzyme cascade. Expand
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
The cell cycle-dependent phosphorylation of Rb is demonstrated and a model to explain how Rb may suppress cell growth by acting as a cell cycle regulatory element is proposed. Expand
Cell cycle regulation of hematopoietic stem cells.
This review focuses on the cell cycle of hematopoietic stem cell and its regulatory mechanisms, and reports that cell cycle arrest of stem cells is mediated through inhibition of pRB phosphorylation and E2F activity, as well as induction of cyclin-dependent kinase (cdk) inhibitors. Expand
A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression.
Findings indicate that the expression of the blood group I antigen in erythrocytes is determined by a novel IGnT3, not byIGnT1 or IGn t2. Expand
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
The results suggest that JAB inhibits IFN signaling by blocking JAK activity, and found that IFN-resistant clones derived from LoVo cells and Daudi cells expressed high levels of JAB without stimulation, which could be, at least in part, a mechanism of IFN resistance. Expand
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.
The present findings suggest that the simultaneous administration of STI571 with other agents except methotrexate would be advantageous for cytotoxic effects against Ph(+) leukemias and these combinations would be worthy of clinical trials. Expand
Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
Functional screening using short hairpin RNA suggests that VLA-4 plays a critical role in CAM-DR of MM cells, and the combination of bortezomib with conventional anti-myeloma drugs may be effective in overcoming CAM- DR of MM. Expand
Lineage‐specific regulation of cell cycle control gene expression during haematopoietic cell differentiation
The results suggest that the expression of cell cycle control genes is distinctively regulated in a lineage‐dependent manner, reflecting the cell cycle characteristics of each lineage. Expand
Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.
It is shown that histone deacetylases (HDACs) are critical targets of bortezomib, which specifically down-regulated the expression of class I HDACs in MM cell lines and primary MM cells at the transcriptional level, accompanied by reciprocal histone hyperacetylation. Expand
Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53*
  • Sanjeev Gupta, V. Radha, Y. Furukawa, Ghanshyam Swarup
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 6 April 2001
It is shown that caspase-1 (interleukin-1β converting enzyme), which plays a role in the production of proinflammatory cytokines and in apoptosis, is a transcriptional target of p53. Expand