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Cell cycle regulation of hematopoietic stem cells.
- Y. Furukawa
- BiologyHuman cell
- 1 June 1998
This review focuses on the cell cycle of hematopoietic stem cell and its regulatory mechanisms, and reports that cell cycle arrest of stem cells is mediated through inhibition of pRB phosphorylation and E2F activity, as well as induction of cyclin-dependent kinase (cdk) inhibitors.
Apaf-1 Is a Mediator of E2F-1-induced Apoptosis*
- Y. Furukawa, N. Nishimura, Mitsuru Nakamura
- Biology, ChemistryThe Journal of Biological Chemistry
- 18 October 2002
A novel mechanism of apoptosis is demonstrated in which an increase in Apaf-1 levels results in direct activation of caspase-9 without mitochondrial damage, leading to the initiation of a casp enzyme cascade.
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression.
Findings indicate that the expression of the blood group I antigen in erythrocytes is determined by a novel IGnT3, not byIGnT1 or IGn t2.
Phosphorylation of Bcl-2 Protein by CDC2 Kinase during G2/M Phases and Its Role in Cell Cycle Regulation*
The results suggest that two distinct functions of Bcl-2 (anti-apoptosis and cell cycle inhibition) are differentially regulated by post-translational mechanisms such as phosphorylation, which may play some physiological roles in the negative regulatory events during mitosis.
Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma.
It is shown that histone deacetylases (HDACs) are critical targets of bortezomib, which specifically down-regulated the expression of class I HDACs in MM cell lines and primary MM cells at the transcriptional level, accompanied by reciprocal histone hyperacetylation.
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.
The present findings suggest that the simultaneous administration of STI571 with other agents except methotrexate would be advantageous for cytotoxic effects against Ph(+) leukemias and these combinations would be worthy of clinical trials.
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
The results suggest that JAB inhibits IFN signaling by blocking JAK activity, and found that IFN-resistant clones derived from LoVo cells and Daudi cells expressed high levels of JAB without stimulation, which could be, at least in part, a mechanism of IFN resistance.
Lineage‐specific regulation of cell cycle control gene expression during haematopoietic cell differentiation
- Y. Furukawa, J. Kikuchi, Mitsuru Nakamura, S. Iwase, Hisashi Yamada, M. Matsuda
- Biology, MedicineBritish journal of haematology
- 1 September 2000
The results suggest that the expression of cell cycle control genes is distinctively regulated in a lineage‐dependent manner, reflecting the cell cycle characteristics of each lineage.