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Prevalence and specificity of LKB1 genetic alterations in lung cancers
Germline LKB1 mutations cause Peutz–Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1… Expand
Antibody-Dependent Cellular Cytotoxicity Mediated by Cetuximab against Lung Cancer Cell Lines
Purpose: Epidermal growth factor receptor (EGFR) is commonly overexpressed in lung cancer. Cetuximab is a chimeric mouse-human antibody targeted against EGFR. Compared with its inhibitory properties,… Expand
Approximate Entropy in the Electroencephalogram during Wake and Sleep
- N. Burioka, M. Miyata, +10 authors E. Shimizu
- Psychology, Medicine
- Clinical EEG and neuroscience
- 1 January 2005
Entropy measurement can discriminate among complex systems, including deterministic, stochastic and composite systems. We evaluated the changes of approximate entropy (ApEn) in signals of the… Expand
Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages.
STUDY OBJECTIVE The breath-to-breath variability of respiratory parameters changes with sleep stage. This study investigates any alteration in the approximate entropy (ApEn) of respiratory movement… Expand
Frequent EGFR mutations in brain metastases of lung adenocarcinoma
- S. Matsumoto, K. Takahashi, +5 authors J. Yokota
- International journal of cancer
- 15 September 2006
Lung adenocarcinomas often metastasize to the brain, and the prognosis of patients with brain metastases is still very poor. The epidermal growth factor receptor (EGFR) gene is mutated in a… Expand
Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.
- T. Hirota, I. Ieiri, +9 authors K. Otsubo
- Biology, Medicine
- Drug metabolism and disposition: the biological…
- 1 May 2003
In this case report, we present genetic differences in two morphine-related gene sequences, UDP-glucuronosyltransferase 2B7 (UGT2B7) and mu opioid receptors (MOR1), in two cancer patients whose… Expand
Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction.
- K. Yoneda, H. Chikumi, +5 authors E. Shimizu
- Biology, Medicine
- FEMS microbiology letters
- 1 February 2005
Multidrug efflux pumps contribute to multiple antibiotic resistance in Pseudomonas aeruginosa. Pump expression usually has been quantified by Western blotting. Quantitative real-time polymerase chain… Expand
The 6-minute pegboard and ring test is correlated with upper extremity activity of daily living in chronic obstructive pulmonary disease
- K. Takeda, Y. Kawasaki, +9 authors E. Shimizu
- International journal of chronic obstructive…
- 23 July 2013
Background Upper-extremity exercise is for pulmonary rehabilitation. The 6-minute pegboard and ring test (6PBRT) was developed to evaluate arm exercise capacity in patients with chronic obstructive… Expand
Expression of functional leukotriene B4 receptors on human airway smooth muscle cells.
- Satoko Watanabe, A. Yamasaki, +13 authors E. Shimizu
- Biology, Medicine
- The Journal of allergy and clinical immunology
- 1 July 2009
BACKGROUND Leukotriene B4 (LTB4) increases in induced sputum and exhaled breath condensate in people with asthma. Furthermore, the T(H)2-type immune response and airway hyperresponsiveness induced by… Expand
Correlation between Asian Dust Storms Worsening Asthma in Western Japan.
- Masanari Watanabe, A. Yamasaki, +16 authors E. Shimizu
- Allergology international : official journal of…
BACKGROUND Severe wind storms during spring in East Asia, called Asian dust storms (ADS), have been assessed in the past for their effect on health in Asian countries. Our objective was to study the… Expand