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The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement and thatquestration of CAR in tight junctions may limit virus infection across epithelial surfaces. Expand
Derivation of androgen‐independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells
The results suggest that certain genetic traits of prostate cancer cells may be selected or altered through an “adaptive” mechanism that involves cellular interaction with the bone stromal cells. Expand
Loss of adenoviral receptor expression in human bladder cancer cells: a potential impact on the efficacy of gene therapy.
It is demonstrated that the expression of adenoviral receptor is variable among human bladder cancer cells, and this variability may have a significant impact on the outcome ofadenovirus-based gene therapy. Expand
Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.
It is indicated that bcl-2 expression is augmented following androgen ablation and is correlated with the progression of prostate cancer from androgen dependence to androgen independence. Expand
The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure.
Data indicate that the cell-cell contact initiated by membrane-bound CAR can elicit a negative signal cascade to modulate cell cycle regulators inside the nucleus of bladder cancer cells, which means that the presence of CAR cannot only facilitate viral uptake of adenovirus but also inhibit cell growth. Expand
AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3.
Data suggest that AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of inhibitor 14-3-3 from AsK1, a novel mechanism by which TNF/JNK activation is significantly blunted in cells where AIP2 is knocked down by RNA interference. Expand
The mitochondrial genome encodes abundant small noncoding RNAs
It is reported that the murine and human mitochondrial genomes encode thousands of small noncoding RNAs, which are predominantly derived from the sense transcripts of the mitochondrial genes (host genes), and they are termed mitochondrial genome-encoded small RNAs (mitosRNAs). Expand
Down-regulation of Human DAB2IP Gene Expression Mediated by Polycomb Ezh2 Complex and Histone Deacetylase in Prostate Cancer*
It is demonstrated that an increased Ezh2 expression in normal prostatic epithelial cells can suppress hDAB2IP gene expression and the methylation status of Lys-27 but not Lys-9 of H3 in hDAB2IP promoter region is consistent with the hDAb2IP levels in both normal prostatics epithelium cells and PCa cells, which provides an underlying mechanism of the down-regulation of h DAB2 IP gene in PCa. Expand
Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors.
Observations from this murine model suggest that androgens and tumor volume are independent determinants of serum PSA levels and imply that decreases in circulating PSA following antiandrogen therapy may not always reflect a corresponding reduction in tumor volume. Expand
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis
  • D. Xie, C. Gore, +12 authors J. Hsieh
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 13 January 2010
It is shown that the loss of DAB2IP expression initiates epithelial-to-mesenchymal transition (EMT), which is visualized by repression of E-cadherin and up-regulation of vimentin in both human normal prostate epithelial and prostate carcinoma cells as well as in clinical prostate-cancer specimens. Expand