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Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.
It is concluded that 2b blocks AGO1 cleavage activity to inhibit miRNA pathways, attenuate RNA silencing, and counter host defense, providing insight on the molecular arms race between host antiviral RNAsilencing and virus counterdefense.
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis.
It is shown that a poorly characterized methyltransferase, CMT2, is a functional methyl transferase in vitro and in vivo and suggest that non-CG methylation patterns are critical in shaping the landscapes of histone modification and small noncoding RNA.
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Key features in molecular recognition of histone PTMs by a diverse family of 'reader pockets', highlighting specific readout mechanisms for individual marks, common themes and insights into the downstream functional consequences of the interactions are summarized.
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
It is demonstrated that the first small-molecule catalytic site inhibitor that is selective for the H3K27me3-specific JMJ subfamily binds in a novel manner and reduces lipopolysaccharide-induced proinflammatory cytokine production by human primary macrophages, a process that depends on both JMJD3 and UTX.
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
The molecular basis for specific recognition of H3(1–15)K4me3 by a plant homeodomains (PHD) finger of human BPTF (bromodomain and PHD domain transcription factor) is demonstrated and key specificity-determining residues from binding studies are identified.
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex.
The availability of the d[AG3(T2AG3)3] solution structure containing four AG3 human telomeric repeats should permit the rational design of ligands that recognize and bind with specificity and affinity to the individual grooves of the G-tetraplex, as well as to either end containing the diagonal and lateral loops.
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs.
The crystal structures of the add A- riboswitch and xpt G-riboswitch aptamer modules are reported that distinguish between bound adenine and guanine with exquisite specificity and modulate expression of two different sets of genes.
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
Consistent with the geometry of the ternary complex, bulges residing in the seed segments of the target, but not the guide strand, were better accommodated and their complexes were catalytically active.
Multivalent engagement of chromatin modifications by linked binding modules
It is proposed that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions.
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
The slicer activity of the RNA-induced silencing complex resides within its Argonaute (Ago) component, in which the PIWI domain provides the catalytic residues governing guide-strand mediated