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Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.
RNA silencing refers to small regulatory RNA-mediated processes that repress endogenous gene expression and defend hosts from offending viruses. As an anti-host defense mechanism, viruses encode… Expand
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis.
DNA methylation occurs in CG and non-CG sequence contexts. Non-CG methylation is abundant in plants and is mediated by CHROMOMETHYLASE (CMT) and DOMAINS REARRANGED METHYLTRANSFERASE (DRM) proteins;… Expand
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
The jumonji (JMJ) family of histone demethylases are Fe2+- and α-ketoglutarate-dependent oxygenases that are essential components of regulatory transcriptional chromatin complexes. These enzymes… Expand
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
- S. Taverna, H. Li, A. Ruthenburg, C. Allis, D. Patel
- Biology, Medicine
- Nature Structural &Molecular Biology
- 1 November 2007
Histones comprise the major protein component of chromatin, the scaffold in which the eukaryotic genome is packaged, and are subject to many types of post-translational modifications (PTMs),… Expand
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Mono-, di- and trimethylated states of particular histone lysine residues are selectively found in different regions of chromatin, thereby implying specialized biological functions for these marks… Expand
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex.
BACKGROUND Repeats of Gn sequences are detected as single strand overhangs at the ends of eukaryotic chromosomes together with associated binding proteins. Such telomere sequences have been… Expand
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
The slicer activity of the RNA-induced silencing complex resides within its Argonaute (Ago) component, in which the PIWI domain provides the catalytic residues governing guide-strand mediated… Expand
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
Here we report on a 3.0 Å crystal structure of a ternary complex of wild-type Thermus thermophilus argonaute bound to a 5′-phosphorylated 21-nucleotide guide DNA and a 20-nucleotide target RNA… Expand
Multivalent engagement of chromatin modifications by linked binding modules
- A. Ruthenburg, H. Li, D. Patel, C. Allis
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 December 2007
Various chemical modifications on histones and regions of associated DNA play crucial roles in genome management by binding specific factors that, in turn, serve to alter the structural properties of… Expand
Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs.
Metabolite-sensing mRNAs, or "riboswitches," specifically interact with small ligands and direct expression of the genes involved in their metabolism. Riboswitches contain sensing "aptamer" modules,… Expand