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Depsipeptide Antineoplastic Antibiotic

Known as: Depsipeptide 
A bicyclic peptide antibiotic with one or more amide bonds replaced by ester bonds. Depsipeptide antibiotics act as histone deacetylase inhibitors… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Depsipeptides

Narrower (1)

romidepsin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.
A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from… 
2014
2014
Fighting bacterial drug resistance by targeting peptidoglycan biosynthesis: Depsipeptide antibiotics and biological probes
2007
2007
Molecular modeling of conformational properties of oligodepsipeptides.
A depsipeptide is a chemical structure consisting of both ester and amide bonds. Quantum mechanics calculations have been… 
Highly Cited
2006
Highly Cited
2006
Cardiotoxicity of Histone Deacetylase Inhibitor Depsipeptide in Patients with Metastatic Neuroendocrine Tumors
Purpose: This phase II study was undertaken to assess objective response and toxicity of histone deacetylase inhibitor… 
Highly Cited
2006
Highly Cited
2006
A phase II study of depsipeptide in refractory metastatic renal cell cancer.
BACKGROUND Therapeutic options for renal cell cancer are inadequate. Depsipeptide is a histone deacetylase inhibitor with… 
2006
2006
Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells.
Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other structural analogues. NNMT gene… 
2005
2005
Responses and molecular markers in patients with peripheral T-cell lymphoma treated on a phase II trial of depsipeptide, FK228
3061 Background: The histone deacetylase inhibitors (HDIs) are a class of differentiating agents undergoing clinical testing… 
Highly Cited
1997
Highly Cited
1997
The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction
Transposon Tn1546 from Enterococcus faecium BM4147 encodes a histidine protein kinase (VanS) and a response regulator (VanR) that… 
1992
1992
Neuropharmacological Mechanism of Action of PF1022A,an Antinematode Anthelmintic with a New Structure of Cyclic Depsipeptide,on Angiostrongylus cantonensis and Isolated Frog Rectus
1972
1972
ION BINDING BY MACROCYCLIC DEPSIPEPTIDE ANTIBIOTICS: MUTUAL
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