Depsipeptide Antineoplastic Antibiotic

Known as: Depsipeptide 
A bicyclic peptide antibiotic with one or more amide bonds replaced by ester bonds. Depsipeptide antibiotics act as histone deacetylase inhibitors… (More)

Topic mentions per year

Topic mentions per year

1963-2016
024619632016

Papers overview

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2009
2009
Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by failure of mature lymphocytes to undergo apoptosis… (More)
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2008
2008
PURPOSE Epigenetic modulation of gene expression plays an important role in cancer, including leukemia. Furthermore, histone… (More)
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2007
2007
The approval by the US Food and Drug Administration (FDA) of the first histone deacetylase (HDAC) inhibitor in October went… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE This phase II study was undertaken to assess objective response and toxicity of histone deacetylase inhibitor… (More)
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2006
2006
PURPOSE Histone acetyltransferases and histone deacetylases (HDAC) control the acetylation state of histones and other proteins… (More)
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2006
2006
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetic profile, and… (More)
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2004
2004
BACKGROUND Immune-compromised individuals are at increased risk for developing aggressive Epstein-Barr virus (EBV)-associated… (More)
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2004
2004
Acetylation of histones by histone acetyl transferases (HATs) leads to transcriptional activation, while histone deacetylase… (More)
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Highly Cited
2002
Highly Cited
2002
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro… (More)
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Highly Cited
1999
Highly Cited
1999
Therapy of B-cell chronic lymphocytic leukemia (CLL) has been limited by both the nonselectivity of therapeutic agents toward… (More)
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