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Depsipeptide Antineoplastic Antibiotic

Known as: Depsipeptide 
A bicyclic peptide antibiotic with one or more amide bonds replaced by ester bonds. Depsipeptide antibiotics act as histone deacetylase inhibitors… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Depsipeptides

Narrower (1)

romidepsin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.
A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from… Expand
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2014
2014
Fighting bacterial drug resistance by targeting peptidoglycan biosynthesis: Depsipeptide antibiotics and biological probes
 
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2007
2007
Molecular modeling of conformational properties of oligodepsipeptides.
A depsipeptide is a chemical structure consisting of both ester and amide bonds. Quantum mechanics calculations have been… Expand
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Highly Cited
2006
Highly Cited
2006
Cardiotoxicity of Histone Deacetylase Inhibitor Depsipeptide in Patients with Metastatic Neuroendocrine Tumors
Purpose: This phase II study was undertaken to assess objective response and toxicity of histone deacetylase inhibitor… Expand
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Highly Cited
2006
Highly Cited
2006
A phase II study of depsipeptide in refractory metastatic renal cell cancer.
BACKGROUND Therapeutic options for renal cell cancer are inadequate. Depsipeptide is a histone deacetylase inhibitor with… Expand
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2006
2006
Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells.
Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other structural analogues. NNMT gene… Expand
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2005
2005
Responses and molecular markers in patients with peripheral T-cell lymphoma treated on a phase II trial of depsipeptide, FK228
3061 Background: The histone deacetylase inhibitors (HDIs) are a class of differentiating agents undergoing clinical testing… Expand
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Highly Cited
1997
Highly Cited
1997
The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction.
Transposon Tn1546 from Enterococcus faecium BM4147 encodes a histidine protein kinase (VanS) and a response regulator (VanR) that… Expand
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1992
1992
Neuropharmacological Mechanism of Action of PF1022A,an Antinematode Anthelmintic with a New Structure of Cyclic Depsipeptide,on Angiostrongylus cantonensis and Isolated Frog Rectus
 
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1972
1972
ION BINDING BY MACROCYCLIC DEPSIPEPTIDE ANTIBIOTICS: MUTUAL
 
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